Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 3/20 | 0.44 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9218801 | 0.87 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2HSP90AA1NFKB1 | |
| SCHEMBL8992766 | 0.86 | LTA4H (0.46) | NPC1RAB9AKMT2ALTA4HALDH1A1 | |
| SCHEMBL9168763 | 0.81 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2HSP90AA1NFKB1 | |
| SCHEMBL3716131 | 0.71 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2HSP90AA1NFKB1 | |
| SCHEMBL23075912 | 0.67 | PLA2G10 (0.47) | PLA2G2APLA2G10KMT2ALTA4HALDH1A1 | |
| Diphenylmethane SCHEMBL18604552 | 0.67 | PLA2G10 (0.71) | PLA2G2APLA2G10SMN1; SMN2MEN1KMT2A | |
| Diphenylmethane SCHEMBL8743340 | 0.67 | PLA2G10 (0.71) | PLA2G2APLA2G10SMN1; SMN2MEN1KMT2A | |
| Diphenylmethane SCHEMBL10451543 | 0.67 | PLA2G10 (0.71) | PLA2G2APLA2G10SMN1; SMN2MEN1KMT2A | |
| Diphenylmethane SCHEMBL28144267 | 0.67 | PLA2G10 (0.71) | PLA2G2APLA2G10SMN1; SMN2MEN1KMT2A | |
| SCHEMBL28806668 | 0.65 | CALM1 (0.63) | PLA2G2APLA2G10LTA4HCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1036919-C | Pyrazole condensed ring derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMA CO LTD (JP) | 1998-01-07 | — | — | CN | disclosed |
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| CN-1089609-A | Pyrazole-fused ring derivatives, its manufacture method and male hormone inhibitor | OTSUKA PHARMA CO LTD (JP) | 1994-07-20 | — | — | CN | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |