Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8993107 | 0.85 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| SCHEMBL1894316 | 0.85 | CA1 (0.57) | CA1CA2LMNAMAPTCA12 | |
| SCHEMBL28823597 | 0.84 | CA1 (0.75) | NPC1KMT2AMEN1CA1CA2 | |
| SCHEMBL6343583 | 0.84 | SMN1; SMN2 (0.57) | NPC1RAB9ASMN1; SMN2TP53MAPK1 | |
| SCHEMBL9149153 | 0.84 | TDP1 (0.51) | RAB9AALDH1A1KMT2AMEN1CA1 | |
| SCHEMBL12019562 | 0.83 | OPRM1 (0.50) | SMN1; SMN2ALDH1A1HPGDAOC3L3MBTL1 | |
| SCHEMBL30251598 | 0.82 | TSHR (0.64) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL866718 | 0.82 | TSHR (0.64) | NPC1RAB9ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL8993085 | 0.82 | ADRB3 (0.50) | NPC1RAB9ASMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL2093768 | 0.82 | AOC3 (0.59) | NPC1RAB9AMAPK1ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |