Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CDC25B | P30305 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8992779 | 0.92 | HSD17B2 (0.61) | HSD17B2SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL8993326 | 0.83 | HSD17B2 (0.59) | HSD17B2SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL8992999 | 0.82 | HSD17B2 (0.58) | HSD17B2SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL14582858 | 0.80 | HSD17B2 (0.68) | HSD17B2SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL5161173 | 0.79 | HSD17B2 (0.66) | HSD17B2SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL10945118 | 0.78 | HSD17B2 (0.73) | HSD17B2SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL3904758 | 0.77 | HSD17B2 (0.62) | HSD17B2SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL30506315 | 0.77 | HSD17B2 (0.76) | HSD17B2SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL1660365 | 0.77 | HSD17B2 (0.76) | HSD17B2SMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL9301797 | 0.76 | RAB9A (0.58) | HSD17B2SMN1; SMN2RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |