Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 12/20 | 0.77 |
| ▸ | TP53 | P04637 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | MAOA | P21397 | 3/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | QPCT | Q16769 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3983367 | 0.87 | MAOB (1.00) | MAOBTP53CYP3A4MAPTMAPK1 | |
| SCHEMBL12369503 | 0.87 | MAOB (0.69) | MAOBTP53CYP3A4MAPTMAPK1 | |
| SCHEMBL13140660 | 0.86 | MAOB (0.65) | MAOBTP53CYP3A4MAPTMAPK1 | |
| SCHEMBL7127282 | 0.85 | MAOB (0.67) | MAOBTP53CYP3A4MAPTMAPK1 | |
| SCHEMBL11850978 | 0.83 | MAOB (0.80) | MAOBMAOA | |
| SCHEMBL28634111 | 0.83 | MAOB (0.63) | MAOBTP53CYP3A4MAPTMAPK1 | |
| SCHEMBL14231743 | 0.82 | MAOB (0.71) | MAOBALDH1A1MAOA | |
| SCHEMBL17149176 | 0.79 | MAOB (0.67) | MAOBTP53CYP3A4MAPTKDM4E | |
| SCHEMBL12279232 | 0.79 | TP53 (0.67) | MAOBTP53CYP3A4MAPTMAPK1 | |
| SCHEMBL10901534 | 0.77 | MAOB (0.70) | MAOBTP53CYP3A4MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120328580-A1 | COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY | 2012-12-27 | — | — | US | disclosed |
| US-8188131-B2 | Compounds that enhance Atoh1 expression | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2012-05-29 | — | — | US | disclosed |
| US-20090232780-A1 | COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090232780-A1 | COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION | DACH1, EZH1, CREBBP | MAOB 2727/4885TP53 740/4885CYP3A4 4758/4885 |
| US-20120328580-A1 | COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION | DACH1, EZH1, CREBBP | MAOB 2727/4885TP53 740/4885CYP3A4 4758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.