SCHEMBL8993450

SCHEMBL8993450

O=C(Cl)CCC1c2ccccc2-c2ccccc21

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 2/20 0.45
TDO2 P48775 1/20 0.41
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
HDAC9 Q9UKV0 1/20 0.40
HDAC5 Q9UQL6 1/20 0.40
NCOR2 Q9Y618 1/20 0.40
TSHR P16473 2/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
POLB P06746 1/20 0.39
KMT2A Q03164 2/20 0.39
CYP1A2 P05177 1/20 0.39
FABP7 O15540 2/20 0.38
FABP5 Q01469 2/20 0.38
EGFR P00533 2/20 0.38
HRH1 P35367 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9449455 0.83 MYC (0.43) HTR2ATSHRCA1CA2CYP1A2
SCHEMBL9449370 0.83 TDO2 (0.37) HTR2ATDO2TSHRPOLBKMT2A
SCHEMBL9449652 0.83 GAA (0.42) HTR2ATSHRKMT2AMAPT
SCHEMBL3136529 0.82 EGFR (0.54) HTR2AHDAC3HDAC4HDAC7HDAC8
SCHEMBL1567120 0.82 HTR2A (0.47) HTR2ATDO2HDAC3HDAC4HDAC7
SCHEMBL23548026 0.81 EGFR (0.55) HTR2ATDO2HDAC3HDAC4HDAC7
Hydrochloric Acid SCHEMBL8993456 0.81 EGFR (0.53) HTR2AHDAC3HDAC4HDAC7HDAC8
SCHEMBL24628375 0.81 POLB (0.47) HTR2AHDAC3HDAC4HDAC7HDAC8
SCHEMBL2108892 0.80 TSHR (0.49) HTR2ATDO2HDAC3HDAC4HDAC7
Hydrochloric Acid SCHEMBL5344416 0.80 SSTR1 (0.54) HTR2AHRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2364988-A1 Stable NAD/NADH derivatives F. Hoffmann-La Roche AG (CH) 2011-09-14 EP disclosed
EP-2364989-A1 Stable NAD/NADH-derivatives F. Hoffmann-La Roche AG (CH) 2011-09-14 EP disclosed
US-5519043-A ANTIINFLAMMATORY AGENTS WITH AMIDE, CARBAMATE OR THIOCARBAMATE GROUPS ON FLUORENE AND BENZENE SCIOS NOVA INC. (US) 1996-05-21 US disclosed
US-5472973-A Non-steroidal antiinflammatory agents SCIOS NOVA INC. (US) 1995-12-05 US disclosed
WO-1993011764-A1 FLUORENYL DERIVATIVES AND THEIR USE AS ANTI-INFLAMMATORY AGENTS SCIOS NOVA INC. (US) 1993-06-24 WO disclosed
EP-0531443-A4 METHODS FOR TREATING INFLAMMATION AND COMPOUNDS AND COMPOSITIONS SUITABLE FOR USE THEREIN 1993-04-21 EP disclosed
EP-0531443-A1 METHODS FOR TREATING INFLAMMATION AND COMPOUNDS AND COMPOSITIONS SUITABLE FOR USE THEREIN NOVA PHARMACEUTICAL CORPORATION (US) 1993-03-17 EP disclosed
US-5079260-A Side effect reduction; fluorene derivatives NOVA PHARMACEUTICAL CORPORATION (US) 1992-01-07 US disclosed
WO-1991018596-A1 METHODS FOR TREATING INFLAMMATION AND COMPOUNDS AND COMPOSITIONS SUITABLE FOR USE THEREIN WEITZBERG MOSHE (US) 1991-12-12 WO disclosed