Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.50 |
| ▸ | MAOB | P27338 | 5/20 | 0.50 |
| ▸ | BCHE | P06276 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | ACSL1 | P33121 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8937140 | 0.90 | MAOA (0.57) | MAOAMAOBBCHEACHEPARP1 | |
| SCHEMBL8937120 | 0.90 | MAOA (0.61) | MAOAMAOBPARP1ROCK1ROCK2 | |
| SCHEMBL8937147 | 0.89 | MAOA (0.51) | MAOAMAOBBCHEACHEPARP1 | |
| SCHEMBL8937161 | 0.87 | ACHE (0.47) | MAOAMAOBACHEPARP1ROCK1 | |
| SCHEMBL8937111 | 0.85 | MAOB (0.58) | MAOAMAOBPARP1ROCK1ROCK2 | |
| SCHEMBL8937152 | 0.85 | MAOA (0.48) | MAOAMAOBPARP1ROCK1ROCK2 | |
| SCHEMBL8987720 | 0.84 | BCHE (0.43) | MAOAMAOBBCHEACHECHRM2 | |
| SCHEMBL4006061 | 0.83 | ROCK1 (0.56) | MAOAMAOBROCK1ROCK2 | |
| SCHEMBL8937188 | 0.83 | MAOA (0.43) | MAOAMAOBPARP1ROCK1MEN1 | |
| SCHEMBL8937175 | 0.83 | MAOA (0.43) | MAOAMAOBPARP1ROCK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188117-B2 | Piperidinyl-substituted isoquinolone derivatives | SANOFI-AVENTIS (FR) | 2012-05-29 | — | — | US | disclosed |