SCHEMBL8993659

SCHEMBL8993659

CC1(C)COC(=O)c2ccc3cc(ccc3c2)C(=O)OC1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSTP1 P09211 2/20 0.38
LPL P06858 1/20 0.37
LIPG Q9Y5X9 1/20 0.37
PTGER3 P43115 5/20 0.36
RARA P10276 3/20 0.35
RARB P10826 3/20 0.35
RARG P13631 3/20 0.35
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
MAPT P10636 1/20 0.34
HPGD P15428 1/20 0.34
PTGS1 P23219 1/20 0.34
PTGS2 P35354 1/20 0.34
WRN Q14191 1/20 0.33
CHRNA1 P02708 1/20 0.33
CHRNG P07510 1/20 0.33
CHRNB1 P11230 1/20 0.33
CHRNB2 P17787 1/20 0.33
SLC6A2 P23975 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL249354 0.86 NPC1 (0.36) ALDH1A1LMNAMAPTHPGDPTGS1
SCHEMBL10484520 0.84 PGR (0.36) ALDH1A1LMNAPTGS1PTGS2
SCHEMBL1758350 0.77 GSTP1 (0.45) GSTP1KDM4EALDH1A1LMNAMAPT
SCHEMBL36556 0.77 GSTP1 (0.45) GSTP1KDM4EALDH1A1MAPTHPGD
SCHEMBL250685 0.74 GSTP1 (0.42) GSTP1RARARARBRARGMAPT
SCHEMBL728514 0.74 GSTP1 (0.42) GSTP1ALDH1A1MAPTNOTUM
SCHEMBL17603299 0.73 TP53 (0.32) KDM4ELMNAMAPT
SCHEMBL5423636 0.72 GSTP1 (0.41) GSTP1RARARARBRARGSLC6A2
SCHEMBL5430449 0.72 GSTP1 (0.41) GSTP1RARARARBRARGSLC6A2
SCHEMBL11577792 0.71 MAOA (0.45) KDM4EALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0526546-B1 SOLID-FORM ADDITIVE SYSTEMS DISPERSIBLE IN AQUEOUS MEDIA EASTMAN CHEM CO (US) 1996-07-17 EP claimed
US-5300256-A Encapsulated EASTMAN CHEMICAL COMPANY (US) 1994-04-05 US claimed
US-5204022-A Heating, adding surfactant EASTMAN KODAK COMPANY (US) 1993-04-20 US claimed
EP-0526546-A1 SOLID-FORM ADDITIVE SYSTEMS DISPERSIBLE IN AQUEOUS MEDIA. EASTMAN KODAK CO (US) 1993-02-10 EP claimed
US-5153029-A Mixing melted polymer additives with surfactants, then with water yields(after agitation) water in oil emulsion which is cooled to give encapsulated emulsion particles EASTMAN KODAK COMPANY (US) 1992-10-06 US claimed
EP-0486600-A1 SOLID-FORM ADDITIVE SYSTEMS DISPERSIBLE IN AQUEOUS MEDIA EASTMAN KODAK COMPANY (US) 1992-05-27 EP claimed
WO-1991016372-A1 SOLID-FORM ADDITIVE SYSTEMS DISPERSIBLE IN AQUEOUS MEDIA EASTMAN KODAK COMPANY (US) 1991-10-31 WO claimed
WO-1991002020-A1 SOLID-FORM ADDITIVE SYSTEMS DISPERSIBLE IN AQUEOUS MEDIA EASTMAN KODAK COMPANY (US) 1991-02-21 WO claimed
EP-0413647-A2 Solid-form additive systems dispersible in aqueous media, methods for the preparation and application thereof to polymeric particles EASTMAN CHEMICAL COMPANY (US) 1991-02-20 EP claimed