SCHEMBL8993791

SCHEMBL8993791

N=C(N)c1ccc(CC(C(=O)O)N2CCC(NS(=O)(=O)c3ccc4ccccc4c3)C2=O)cc1

nearest known ligand 0.63

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
F2 P00734 9/20 0.63
PRSS1 P07477 2/20 0.63
PRSS2 P07478 1/20 0.63
PRSS3 P35030 1/20 0.63
F10 P00742 17/20 0.61
PLG P00747 2/20 0.61
PROC P04070 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8993790 0.95 F2 (0.66) F2PRSS1PRSS2PRSS3F10
SCHEMBL8993724 0.90 F10 (0.73) F2PRSS1F10PLGPROC
SCHEMBL8993740 0.90 F2 (0.58) F2PRSS1PRSS2PRSS3F10
SCHEMBL8993767 0.90 F2 (0.62) F2PRSS1PRSS2PRSS3F10
SCHEMBL8993800 0.90 F10 (0.70) F2PRSS1F10PLGPROC
SCHEMBL8993743 0.89 F10 (0.63) F2PRSS1PRSS2PRSS3F10
SCHEMBL8993711 0.89 F10 (0.54) F2PRSS1PRSS2PRSS3F10
SCHEMBL7449093 0.88 F10 (0.60) F2PRSS1PRSS2PRSS3F10
SCHEMBL8993691 0.86 F2 (0.64) F2PRSS1PRSS2PRSS3F10
SCHEMBL8993694 0.86 F2 (0.61) F2PRSS1PRSS2PRSS3F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5489583-A FOR TREATING OR PREVENTING THROMBOSIS BASF AKTIENGESELLSCHAFT (DE) 1996-02-06 US disclosed