Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 11/20 | 0.57 |
| ▸ | SRD5A1 | P18405 | 5/20 | 0.57 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8994129 | 0.91 | SRD5A2 (0.66) | SRD5A2SRD5A1PSEN1PSEN2APH1B | |
| SCHEMBL8994120 | 0.88 | SRD5A2 (0.59) | SRD5A2SRD5A1ESR1ARESR2 | |
| SCHEMBL8994093 | 0.86 | SRD5A2 (0.62) | SRD5A2SRD5A1ESR1ARESR2 | |
| SCHEMBL9392669 | 0.84 | SRD5A2 (0.66) | SRD5A2SRD5A1ESR1ARESR2 | |
| SCHEMBL8994119 | 0.84 | SRD5A2 (0.49) | SRD5A2SRD5A1PSEN1PSEN2APH1B | |
| SCHEMBL8994118 | 0.84 | SRD5A2 (0.57) | SRD5A2SRD5A1ESR1ARESR2 | |
| SCHEMBL9393593 | 0.84 | SRD5A2 (0.62) | SRD5A2SRD5A1ESR1ARESR2 | |
| SCHEMBL8994170 | 0.83 | SRD5A2 (0.69) | SRD5A2SRD5A1ESR1ARESR2 | |
| SCHEMBL8994155 | 0.83 | SRD5A2 (0.56) | SRD5A2SRD5A1 | |
| SCHEMBL8151554 | 0.82 | SRD5A2 (0.83) | SRD5A2SRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721460-A1 | 3-CARBOXYSTEROIDS WITH A FLUORINATED SIDE CHAIN | PHARMACIA & UPJOHN S.p.A. (IT) | 1996-07-17 | — | — | EP | disclosed |
| WO-1996003420-A1 | 3-CARBOXYSTEROIDS WITH A FLUORINATED SIDE CHAIN | PHARMACIA S.P.A. (IT) | 1996-02-08 | — | — | WO | disclosed |