Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 8/20 | 0.47 |
| ▸ | ACE | P12821 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8994570 | 1.00 | FKBP1A (0.47) | FKBP1AACELMNAMMP13MMP8 | |
| SCHEMBL7282610 | 0.90 | FKBP1A (0.48) | FKBP1AACEMMP13MMP8MMP12 | |
| SCHEMBL7282612 | 0.90 | FKBP1A (0.48) | FKBP1AACEMMP13MMP8MMP12 | |
| SCHEMBL9289142 | 0.89 | ACE (0.54) | ACELMNASMN1; SMN2 | |
| SCHEMBL8994547 | 0.89 | ACE (0.54) | ACELMNASMN1; SMN2 | |
| SCHEMBL8994535 | 0.84 | ACE (0.44) | FKBP1AACELMNASMN1; SMN2 | |
| SCHEMBL8994542 | 0.84 | ACE (0.44) | FKBP1AACELMNASMN1; SMN2 | |
| SCHEMBL9247684 | 0.84 | ACE (0.44) | FKBP1AACELMNASMN1; SMN2 | |
| SCHEMBL7324514 | 0.80 | DPP4 (0.42) | FKBP1AMMP13MMP8MMP12 | |
| SCHEMBL7285065 | 0.79 | DPP4 (0.41) | FKBP1AACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5545657-A | 1-ALKYLOYLPYRROLIDIN-2-YLOXOALKANOIC ACIDS AND DERIVATIVES; ANTIAMNESIA AGENTS; INHIBITORS OF PROLYL ENDOPEPTIDASE; SUPPRESSION OF NEUROTRANSMITTER METABOLISM | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-08-13 | — | — | US | disclosed |
| US-5451604-A | Useful in organ transplant surgery | G. D. SEARLE & CO. (US) | 1995-09-19 | — | — | US | disclosed |
| US-5411974-A | Thiazoline derivatives, treatment of amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-05-02 | — | — | US | disclosed |
| US-5212191-A | Thiazoline derivatives for treatment of amnesia | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-05-18 | — | — | US | disclosed |