Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2233013 | 0.98 | ADRB2 (0.60) | ADRB2KDM4EMAPTTDP1GRIN2B | |
| Hydrochloric Acid SCHEMBL2535765 | 0.97 | ADRB2 (0.58) | ADRB2KDM4EMAPTTDP1GRIN2B | |
| Bromide SCHEMBL8994861 | 0.76 | ADRB2 (0.97) | ADRB2KDM4EMAPTTDP1GRIN2B | |
| Hydrochloric Acid SCHEMBL8994876 | 0.75 | ADRB2 (0.43) | ADRB2KDM4EMAPTTDP1GRIN2B | |
| SCHEMBL2233005 | 0.74 | ADRB2 (1.00) | ADRB2KDM4EMAPTTDP1GRIN2B | |
| SCHEMBL6657867 | 0.73 | PDE3B (0.45) | ADRB2KDM4EMAPTTDP1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL2535761 | 0.73 | ADRB2 (0.97) | ADRB2KDM4EMAPTTDP1GRIN2B | |
| SCHEMBL28171197 | 0.70 | TYMS (0.38) | ADRB2KDM4EMAPTTDP1ALDH1A1 | |
| SCHEMBL13383928 | 0.70 | ALDH1A1 (0.48) | KDM4EMAPTTDP1ALDH1A1PKM | |
| SCHEMBL4624598 | 0.68 | KDM4E (0.51) | ADRB2KDM4EMAPTTDP1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5589437-A | Method of using 5-hydroxybenzimidazole compounds for reducing transpiration in plants | VICHNEVETSKAIA KLARA D (CA) | 1996-12-31 | — | — | US | disclosed |