Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.54 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.52 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ACHE | P22303 | 4/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8995074 | 0.99 | LTB4R (0.53) | LTB4RLTB4R2PLA2G4BCYP1A2HSP90AA1 | |
| Hydrochloric Acid SCHEMBL8994964 | 0.95 | LTB4R (0.51) | LTB4RLTB4R2PLA2G4BCYP1A2HSP90AA1 | |
| Hydrochloric Acid SCHEMBL8995033 | 0.91 | LTB4R (0.52) | LTB4RLTB4R2PLA2G4BMAPTACHE | |
| Hydrochloric Acid SCHEMBL8994907 | 0.89 | LTB4R (0.55) | LTB4RLTB4R2PLA2G4BMAPTPRSS1 | |
| SCHEMBL7711975 | 0.87 | LTB4R (0.72) | LTB4RLTB4R2PLA2G4BMAPTACHE | |
| Hydrochloric Acid SCHEMBL8994890 | 0.86 | LTB4R (0.71) | LTB4RLTB4R2PLA2G4BMAPTACHE | |
| Hydrochloric Acid SCHEMBL8994949 | 0.86 | HRH3 (0.50) | PLA2G4BMAPTACHEALDH1A1LMNA | |
| SCHEMBL9702013 | 0.85 | LTB4R (0.68) | LTB4RLTB4R2PLA2G4BMAPTPRSS1 | |
| SCHEMBL8994985 | 0.85 | LTB4R (0.68) | LTB4RLTB4R2PLA2G4BMAPTPRSS1 | |
| Hydrochloric Acid SCHEMBL8995024 | 0.84 | LTB4R (0.51) | LTB4RLTB4R2PLA2G4BMAPTACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | claimed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | claimed |
| EP-0518819-A2 | Amidino compounds, their manufacture and use as medicament | CIBA-GEIGY AG (CH) | 1992-12-16 | — | — | EP | claimed |