Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.71 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.64 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.45 |
| ▸ | F2 | P00734 | 3/20 | 0.45 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.45 |
| ▸ | PLAU | P00749 | 2/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.45 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.45 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | S100B | P04271 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8994959 | 0.91 | LTB4R (0.73) | LTB4RLTB4R2PRMT1F2ST14 | |
| SCHEMBL8994948 | 0.87 | LTB4R (0.59) | LTB4RLTB4R2THRATHRBBCL2L1 | |
| Hydrochloric Acid SCHEMBL8994874 | 0.84 | LTB4R (0.76) | LTB4RLTB4R2PRMT1F2ST14 | |
| SCHEMBL9117722 | 0.84 | LTB4R (0.75) | LTB4RLTB4R2PRMT1F2ST14 | |
| SCHEMBL14378909 | 0.84 | LTB4R (0.94) | LTB4RLTB4R2PRMT1F2ST14 | |
| Hydrochloric Acid SCHEMBL8995014 | 0.83 | LTB4R (0.92) | LTB4RLTB4R2PRMT1F2ST14 | |
| Moxilubant SCHEMBL6439215 | 0.83 | LTB4R (1.00) | LTB4RLTB4R2PRMT1F2ST14 | |
| Hydrochloric Acid SCHEMBL8994909 | 0.83 | LTB4R (0.74) | LTB4RLTB4R2PRMT1F2ST14 | |
| Moxilubant SCHEMBL29388138 | 0.83 | LTB4R (1.00) | LTB4RLTB4R2PRMT1F2ST14 | |
| Hydrochloric Acid SCHEMBL8994935 | 0.83 | LTB4R (0.73) | LTB4RLTB4R2PRMT1F2ST14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |