Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.59 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.54 |
| ▸ | THRA | P10827 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.44 |
| ▸ | LSS | P48449 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8995071 | 0.92 | LTB4R (0.56) | LTB4RLTB4R2THRATHRBBCL2L1 | |
| Hydrochloric Acid SCHEMBL8994980 | 0.91 | LTB4R (0.56) | LTB4RLTB4R2THRATHRBBCL2L1 | |
| SCHEMBL8994971 | 0.87 | LTB4R (0.71) | LTB4RLTB4R2THRATHRBBCL2L1 | |
| SCHEMBL8994945 | 0.85 | LTB4R (0.55) | LTB4RLTB4R2PLA2G4BHTT | |
| SCHEMBL8994887 | 0.84 | LTB4R (0.76) | LTB4RLTB4R2THRATHRBBCL2L1 | |
| SCHEMBL8994878 | 0.83 | LTB4R (0.50) | LTB4RLTB4R2THRATHRBPLA2G4B | |
| Hydrochloric Acid SCHEMBL8590502 | 0.83 | LTB4R (0.48) | LTB4RLTB4R2THRATHRBPLA2G4B | |
| SCHEMBL8591184 | 0.82 | LTB4R (0.48) | LTB4RLTB4R2PLA2G4BHTT | |
| Hydrochloric Acid SCHEMBL8994959 | 0.82 | LTB4R (0.73) | LTB4RLTB4R2 | |
| SCHEMBL8995079 | 0.82 | LTB4R (0.48) | LTB4RLTB4R2THRATHRBLSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |