Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.56 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.52 |
| ▸ | THRA | P10827 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.42 |
| ▸ | LSS | P48449 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8994980 | 0.99 | LTB4R (0.56) | LTB4RLTB4R2THRATHRBBCL2L1 | |
| SCHEMBL8994948 | 0.92 | LTB4R (0.59) | LTB4RLTB4R2THRATHRBBCL2L1 | |
| Hydrochloric Acid SCHEMBL8590502 | 0.91 | LTB4R (0.48) | LTB4RLTB4R2THRATHRBPLA2G4B | |
| SCHEMBL8591184 | 0.90 | LTB4R (0.48) | LTB4RLTB4R2PLA2G4BHTT | |
| SCHEMBL8994878 | 0.90 | LTB4R (0.50) | LTB4RLTB4R2THRATHRBPLA2G4B | |
| Hydrochloric Acid SCHEMBL8589791 | 0.89 | LTB4R (0.47) | LTB4RLTB4R2THRATHRBPLA2G4B | |
| Hydrochloric Acid SCHEMBL8593811 | 0.89 | LTB4R (0.48) | LTB4RLTB4R2THRATHRBHTT | |
| Hydrochloric Acid SCHEMBL8593266 | 0.89 | LTB4R (0.46) | LTB4RLTB4R2THRATHRB | |
| SCHEMBL8995079 | 0.88 | LTB4R (0.48) | LTB4RLTB4R2THRATHRBLSS | |
| Hydrochloric Acid SCHEMBL8591953 | 0.88 | LTB4R (0.46) | LTB4RLTB4R2THRATHRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |
| EP-0518819-A2 | Amidino compounds, their manufacture and use as medicament | CIBA-GEIGY AG (CH) | 1992-12-16 | — | — | EP | disclosed |