Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | NPC1 | O15118 | 3/20 | 0.68 |
| ▸ | RAB9A | P51151 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | ITK | Q08881 | 2/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1429201 | 0.82 | NPC1 (1.00) | MAPTKDM4ENPC1RAB9AMEN1 | |
| SCHEMBL27944096 | 0.77 | NPC1 (0.88) | MAPTKDM4ENPC1RAB9AMEN1 | |
| SCHEMBL2545686 | 0.77 | MAPT (0.62) | MAPTKDM4ENPC1RAB9AMEN1 | |
| SCHEMBL15073408 | 0.76 | KDM4E (0.82) | MAPTKDM4ENPC1RAB9AMEN1 | |
| SCHEMBL3009057 | 0.75 | KDM4E (0.79) | MAPTKDM4ENPC1RAB9AMEN1 | |
| SCHEMBL8995284 | 0.74 | KDM4E (0.76) | MAPTKDM4ENPC1RAB9AMEN1 | |
| SCHEMBL4264688 | 0.73 | KDM4E (0.81) | MAPTKDM4ENPC1RAB9AMEN1 | |
| SCHEMBL10832443 | 0.72 | NPC1 (0.75) | MAPTKDM4ENPC1RAB9AMEN1 | |
| SCHEMBL11058048 | 0.72 | MAPT (0.64) | MAPTKDM4ENPC1RAB9AMEN1 | |
| SCHEMBL15073440 | 0.71 | KDM4E (0.73) | MAPTKDM4ENPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5496844-A | Indole derivatives | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0639567-A1 | INDOLE DERIVATIVE | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1995-02-22 | — | — | EP | disclosed |