Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 6/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.43 |
| ▸ | TYMS | P04818 | 3/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bropirimine SCHEMBL509127 | 0.82 | XDH (1.00) | XDHKDM4EMEN1MAPTKMT2A | |
| SCHEMBL1555448 | 0.79 | XDH (0.59) | XDHPIK3CGADORA2ATYMSADORA1 | |
| SCHEMBL29416781 | 0.77 | XDH (0.52) | XDHTYMS | |
| SCHEMBL18748036 | 0.74 | ADORA2A (0.57) | ADORA2AADORA1ADORA2BDPP4KDM4E | |
| SCHEMBL10843906 | 0.73 | BACE1 (0.48) | ADORA2AADORA1ADORA2BDPP4KDM4E | |
| SCHEMBL5189442 | 0.72 | XDH (0.48) | XDHADORA2AADORA1ADORA2BKMT2A | |
| SCHEMBL7776236 | 0.71 | ADORA2A (0.55) | PIK3CGADORA2AADORA1ADORA2BDPP4 | |
| SCHEMBL10569841 | 0.69 | XDH (1.00) | XDHTYMSKDM4EMEN1MAPT | |
| SCHEMBL29736870 | 0.69 | TYMS (0.50) | XDHTYMS | |
| SCHEMBL17667854 | 0.68 | ADORA2A (0.62) | ADORA2AADORA1ADORA2BDPP4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4308272-A | HALO-SUBSTITUTED 2-AMINOPYRIMIDINONES | THE UPJOHN COMPANY (US) | 1981-12-29 | — | — | US | claimed |
| US-5554617-A | Method for treating cancer with 6-aryl pyrimidine compounds | THE UPJOHN COMPANY (US) | 1996-09-10 | — | — | US | disclosed |
| US-5434157-A | Active against herpes, hepatitis, papovavirus | THE UPJOHN COMPANY (US) | 1995-07-18 | — | — | US | disclosed |
| US-5002951-A | 2-amino-5-halo-4-pyrimidinol for bactericides and antiprotozoa agent | THE UPJOHN COMPANY (US) | 1991-03-26 | — | — | US | disclosed |
| US-4665077-A | IMMUNOREGULATORY AGENTS | THE UPJOHN COMPANY (US) | 1987-05-12 | — | — | US | disclosed |
| US-4619933-A | 6-aryl pyrimidines for treating aplastic anemia | THE UPJOHN COMPANY (US) | 1986-10-28 | — | — | US | disclosed |
| US-4543248-A | Method for immunoregulation with 6-aryl pyrimidine compounds | THE UPJOHN COMPANY (US) | 1985-09-24 | — | — | US | disclosed |
| US-4507302-A | Method for treating arthritis with 6-aryl pyrimidine compounds | THE UPJOHN COMPANY (US) | 1985-03-26 | — | — | US | disclosed |
| US-4308272-A | HALO-SUBSTITUTED 2-AMINOPYRIMIDINONES | THE UPJOHN COMPANY (US) | 1981-12-29 | — | — | US | disclosed |