Bropirimine

Bropirimine

SCHEMBL509127

Nc1nc(-c2ccccc2)c(Br)c(=O)[nH]1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
XDH P47989 8/20 1.00
QTRT1 Q9BXR0 1/20 0.50
FGFR1 P11362 1/20 0.50
FGFR2 P21802 1/20 0.50
NOS1 P29475 1/20 0.47
ACMSD Q8TDX5 1/20 0.44
CDK5 Q00535 1/20 0.44
CDK5R1 Q15078 1/20 0.44
KDM4E B2RXH2 1/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
MEN1 O00255 1/20 0.44
ALDH1A1 P00352 1/20 0.44
MAPT P10636 1/20 0.44
HPGD P15428 1/20 0.44
KMT2A Q03164 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
DHFR P00374 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8995826 0.82 XDH (0.68) XDHKDM4EMEN1MAPTKMT2A
SCHEMBL8677237 0.81 XDH (0.68) XDHKDM4ENPC1RAB9AMEN1
SCHEMBL10570830 0.79 XDH (0.68) XDHQTRT1FGFR1FGFR2NOS1
SCHEMBL10569841 0.79 XDH (1.00) XDHQTRT1FGFR1FGFR2NOS1
SCHEMBL2772506 0.76 XDH (0.68) XDHQTRT1FGFR1FGFR2NOS1
SCHEMBL13377864 0.76 XDH (0.65) XDHQTRT1FGFR1FGFR2NOS1
SCHEMBL2572687 0.76 XDH (1.00) XDHACMSDKDM4EMEN1ALDH1A1
SCHEMBL5383503 0.74 MAPK13 (0.60) XDHALDH1A1MAPTHPGD
SCHEMBL5157870 0.74 XDH (0.59) XDHCDK5CDK5R1KDM4ENPC1
SCHEMBL1023569 0.73 PIK3CG (0.70) XDHQTRT1FGFR1FGFR2NOS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 484 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250206708-A1 AN OXAZIRIDINE PLATFORM FOR TARGETING FUNCTIONAL ALLOSTERIC METHIONINE SITES NOVARTIS AG (CH) 2025-06-26 US claimed
EP-4538708-A1 METHOD FOR IMPROVING EXPERIMENTAL FLUX OF INTERACTION BETWEEN COMPOUNDS AND PROTEINS Southern University of Science and Technology (CN) 2025-04-16 EP claimed
US-20250095772-A1 METHOD FOR IMPROVING THROUGHPUT OF COMPOUND-PROTEIN INTERACTION EXPERIMENTS SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2025-03-20 US claimed
CN-119628087-A Power system optimal configuration method for promoting rural renewable energy consumption 国网河南省电力公司经济技术研究院 2025-03-14 CN claimed
CN-119409758-A ABPP-based anti-inflammatory 18 beta-glycyrrhetinic acid active molecular probe, synthesis and application 武汉轻工大学 2025-02-11 CN claimed
EP-4499617-A1 AN OXAZIRIDINE PLATFORM FOR TARGETING FUNCTIONAL ALLOSTERIC METHIONINE SITES Novartis AG (CH) 2025-02-05 EP claimed
CN-119078328-A Polyolefin material with soft surface performance for laminating film, and preparation method and application thereof 黄山永新股份有限公司 2024-12-06 CN claimed
CN-118257004-A Method for screening molecular library from molecular library of DCL-ABPP 华南理工大学 2024-06-28 CN claimed
WO-2024133743-A1 METHOD FOR DIAGNOSING AND/OR CLASSIFYING THE SEVERITY OF A NEURODEGENERATIVE DISEASE EM Scientific Limited (GB) 2024-06-27 WO claimed
CN-117723760-A Application of TMEM43 protein as fibrosis disease treatment target 深圳大学 2024-03-19 CN claimed
CN-116648509-A Methods and compositions for producing a recombinant component for food products and other products 完美日股份有限公司 2023-08-25 CN claimed
US-20230147129-A1 COMPOUNDS FOR USE IN THE TREATMENT OF SYNUCLEINOPATHIES UNIVERSITAT AUTÒNOMA DE BARCELONA (ES) 2023-05-11 US claimed
CN-116029157-A Rural power system power supply configuration method for biomass power generation access and terminal equipment 国网河南省电力公司经济技术研究院 2023-04-28 CN claimed
WO-2022104227-A9 METHODS AND COMPOSITIONS FOR PRODUCING RECOMBINANT COMPONENTS FOR USE IN FOOD AND OTHER PRODUCTS Perfect Day, Inc. (US) 2023-04-20 WO claimed
EP-4125840-A1 COMPOUNDS FOR USE IN THE TREATMENT OF SYNUCLEINOPATHIES Som Innovation Biotech, S.A. (ES) 2023-02-08 EP claimed
WO-2022104227-A1 METHODS AND COMPOSITIONS FOR PRODUCING RECOMBINANT COMPONENTS FOR USE IN FOOD AND OTHER PRODUCTS Perfect Day, Inc. (US) 2022-05-19 WO claimed
WO-2021191417-A1 COMPOUNDS FOR USE IN THE TREATMENT OF SYNUCLEINOPATHIES SOM INNOVATION BIOTECH, S.A. (ES) 2021-09-30 WO claimed
CN-101918566-A By influencing the transfection results that innate immune system improves non-viral delivery system BIONTEX LAB GMBH 2010-12-15 CN claimed
EP-2212425-A2 IMPROVEMENT OF TRANSFECTION RESULTS OF NON-VIRAL GENE DELIVERY SYSTEMS BY INFLUENCING THE CONGENITAL IMMUNE SYSTEM Biontex Laboratories Gmbh (DE) 2010-08-04 EP claimed
WO-2009065618-A2 IMPROVEMENT OF TRANSFECTION RESULTS OF NON-VIRAL GENE DELIVERY SYSTEMS BY INFLUENCING THE CONGENITAL IMMUNE SYSTEM BIONTEX LABORATORIES GMBH (DE) 2009-05-28 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250206708-A1 AN OXAZIRIDINE PLATFORM FOR TARGETING FUNCTIONAL ALLOSTERIC METHIONINE SITES MARCKS, PTMS, DMPK XDH 4278/4885QTRT1 3618/4885FGFR1 2813/4885
US-20230147129-A1 COMPOUNDS FOR USE IN THE TREATMENT OF SYNUCLEINOPATHIES SNCA, PARK7, PRNP XDH 1449/4885QTRT1 3290/4885FGFR1 4354/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.