Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.44 |
| ▸ | PPARG known ✓ | P37231 | 1/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8995935 | 0.96 | GRIK1 (0.49) | GRIK1KDM4EMEN1KMT2AHDAC3 | |
| SCHEMBL23934240 | 0.94 | GRIK1 (0.55) | GRIK1KDM4EMEN1KMT2AHDAC3 | |
| SCHEMBL375312 | 0.94 | GRIK1 (0.55) | GRIK1KDM4EMEN1KMT2AHDAC3 | |
| SCHEMBL7043922 | 0.91 | GRIK1 (0.45) | GRIK1KDM4EMEN1KMT2AHDAC3 | |
| Juarezic Acid SCHEMBL9093401 | 0.91 | GRIK1 (0.47) | GRIK1KDM4EMEN1KMT2AHDAC3 | |
| Ethyl Fumarate SCHEMBL1452094 | 0.91 | HCAR2 (0.46) | GRIK1KDM4EMEN1KMT2AHCAR2 | |
| Acrylic Acid SCHEMBL8470543 | 0.90 | GRIK1 (0.49) | GRIK1KDM4EMEN1KMT2AHDAC3 | |
| SCHEMBL6982746 | 0.90 | GRIK1 (0.49) | GRIK1KDM4EMEN1KMT2AHDAC3 | |
| SCHEMBL393958 | 0.90 | GRIK1 (0.54) | GRIK1KDM4EMEN1KMT2AHDAC3 | |
| SCHEMBL7107526 | 0.89 | TDP1 (0.52) | GRIK1KDM4EMEN1KMT2AHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5532101-A | CHARGING CYLINDRICAL PHOTOSENSITIVE MEMBER, ROTATING, EXPOSING TO FORM ELECTROSTATICALLY CHARGED IMAGE, DEVELOPING WITH TONER OF SPECIFIED TRIBOELECTRIC CHARGE, CONTACT TRANSFERRING IMAGE, CLEANING RESIDUAL TONER PARTICLES | CANON KABUSHIKI KAISHA (JP) | 1996-07-02 | — | — | US | disclosed |