SCHEMBL8996008

SCHEMBL8996008

COc1ccc(C#N)c(Cl)c1O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.53
KDM4E B2RXH2 2/20 0.53
USP2 O75604 1/20 0.53
IMPDH2 P12268 1/20 0.49
IMPDH1 P20839 1/20 0.49
AR P10275 8/20 0.43
PGR P06401 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.42
TSHR P16473 1/20 0.42
MAOA P21397 2/20 0.41
MAOB P27338 2/20 0.41
LMNA P02545 1/20 0.39
TP53 P04637 1/20 0.39
CYP3A4 P08684 1/20 0.39
MAPT P10636 1/20 0.39
HPGD P15428 1/20 0.39
ALOX15 P16050 1/20 0.39
ALOX12 P18054 1/20 0.39
MAPK1 P28482 1/20 0.39
HSD17B10 Q99714 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7691509 0.82 ALDH1A1 (0.58) ALDH1A1KDM4EUSP2IMPDH2IMPDH1
SCHEMBL7366475 0.79 ALDH1A1 (0.50) ALDH1A1KDM4EUSP2IMPDH2IMPDH1
SCHEMBL28905705 0.78 ALDH1A1 (0.49) ALDH1A1KDM4EUSP2IMPDH2IMPDH1
SCHEMBL3272602 0.78 ALDH1A1 (0.49) ALDH1A1KDM4EUSP2IMPDH2IMPDH1
SCHEMBL3027438 0.77 ALDH1A1 (0.61) ALDH1A1KDM4EUSP2IMPDH2IMPDH1
SCHEMBL945003 0.77 ALDH1A1 (0.61) ALDH1A1KDM4EUSP2IMPDH2IMPDH1
SCHEMBL29615609 0.77 ALDH1A1 (0.61) ALDH1A1KDM4EUSP2IMPDH2IMPDH1
SCHEMBL6954237 0.76 ALDH1A1 (0.50) ALDH1A1KDM4EUSP2IMPDH2IMPDH1
SCHEMBL24495415 0.74 ALDH1A1 (0.49) ALDH1A1KDM4EUSP2IMPDH2IMPDH1
SCHEMBL5469559 0.74 MAPK1 (0.52) ALDH1A1KDM4ETSHRMAOBLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0537742-B1 Styrene derivatives MITSUBISHI CHEM CORP (JP) 1996-08-21 EP disclosed
US-5514711-A ANTICARCINOGENIC AGENTS; SIDE EFFECT REDUCTION MITSUBISHI CHEMICAL CORPORATION (JP) 1996-05-07 US disclosed
EP-0537742-A2 Styrene derivatives Mitsubishi Chemical Corporation (JP) 1993-04-21 EP disclosed