Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 11/20 | 0.58 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.57 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.56 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.56 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | PTAFR | P25105 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5353235 | 0.93 | TBXAS1 (0.62) | TBXAS1MKNK1MKNK2ALDH1A1APP | |
| SCHEMBL11067952 | 0.86 | TBXAS1 (0.67) | TBXAS1MKNK1MKNK2ALDH1A1APP | |
| Hydrochloric Acid SCHEMBL11062270 | 0.85 | TBXAS1 (0.68) | TBXAS1MKNK1MKNK2ALDH1A1APP | |
| Hydrochloric Acid SCHEMBL9378196 | 0.83 | TBXAS1 (0.54) | TBXAS1NAPRTMEN1NPC1RAB9A | |
| Aminomethylbenzoic Acid SCHEMBL5211981 | 0.83 | MKNK1 (0.54) | TBXAS1MKNK1MKNK2ALDH1A1APP | |
| SCHEMBL20236126 | 0.82 | CYP1A2 (0.66) | MKNK1MKNK2ALDH1A1APPGAA | |
| SCHEMBL1566393 | 0.81 | CYP3A4 (0.73) | ALDH1A1GAAKMT2ASMN1; SMN2CYP1A2 | |
| SCHEMBL27708002 | 0.81 | TBXAS1 (0.52) | TBXAS1MKNK1MKNK2KMT2ATRPV1 | |
| SCHEMBL8700016 | 0.81 | CYP1A2 (0.66) | TBXAS1NAPRTCYP1A2CHRNA7 | |
| SCHEMBL1926270 | 0.81 | HDAC1 (0.64) | ALDH1A1NAPRT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5563151-A | PLATELET ACTIVATING FACTOR RECEPTOR ANTAGONISTS; ANTIINFLAMMATORY AGENTS, ANALGESICS | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1996-10-08 | — | — | US | disclosed |
| EP-0623116-A1 | AMINO ACID DERIVATIVES AS PAF-RECEPTOR ANTAGONISTS | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1994-11-09 | — | — | EP | disclosed |
| WO-1993014072-A1 | AMINO ACID DERIVATIVES AS PAF-RECEPTOR ANTAGONISTS | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-07-22 | — | — | WO | disclosed |