Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.42 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.42 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
| ▸ | GPR3 | P46089 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | TACR2 | P21452 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SHBG | P04278 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11106081 | 0.88 | SKP2 (0.42) | SKP2GPR3ESR1ADRA2AADORA3 | |
| Bromide SCHEMBL11105865 | 0.81 | KAT8 (0.43) | GPR3ESR1ADRA2AADORA3TACR2 | |
| Hydrochloric Acid SCHEMBL29624926 | 0.79 | PTGS2 (0.46) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL7529714 | 0.79 | SKP2 (0.50) | SKP2GPR3ESR1ADRA2AADORA3 | |
| Hydrochloric Acid SCHEMBL66010 | 0.78 | ESR1 (0.57) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| Hydrochloric Acid SCHEMBL8042065 | 0.76 | MEN1 (0.38) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL12114083 | 0.76 | ESR1 (0.59) | ESR1ADRA2AADORA3TACR2SLC6A2 | |
| SCHEMBL10608353 | 0.76 | SKP2 (0.58) | SKP2GPR3ESR1ADRA2AADORA3 | |
| SCHEMBL9298886 | 0.76 | SKP2 (0.58) | SKP2GPR3ESR1ADRA2AADORA3 | |
| SCHEMBL27976435 | 0.75 | TYR (0.46) | ESR1ADRA2AADORA3TACR2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0402094-B1 | Process for measuring body fluid components | WAKO PURE CHEM IND LTD (JP) | 1996-08-28 | — | — | EP | disclosed |
| US-5384248-A | Process for measuring an analyte with an oxidase and an oxidizable color reagent and surfactants | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 1995-01-24 | — | — | US | disclosed |
| EP-0402094-A2 | Process for measuring body fluid components | WAKO PURE CHEMICAL INDUSTRIES LTD (JP) | 1990-12-12 | — | — | EP | disclosed |