Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | DNM1 | Q05193 | 9/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.50 |
| ▸ | RAD52 | P43351 | 2/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL15261656 | 0.91 | DNM1 (0.65) | ALDH1A1TSHRDNM1HSP90AA1RAD52 | |
| Bromide SCHEMBL28602069 | 0.91 | DNM1 (0.65) | ALDH1A1TSHRDNM1HSP90AA1RAD52 | |
| Bromide SCHEMBL15261195 | 0.91 | DNM1 (0.65) | ALDH1A1TSHRDNM1HSP90AA1RAD52 | |
| Bromide SCHEMBL15261228 | 0.91 | DNM1 (0.65) | ALDH1A1TSHRDNM1HSP90AA1RAD52 | |
| Bromide SCHEMBL15260870 | 0.91 | DNM1 (0.65) | ALDH1A1TSHRDNM1HSP90AA1RAD52 | |
| SCHEMBL23644568 | 0.88 | DNM1 (0.64) | ALDH1A1TSHRDNM1HSP90AA1RAD52 | |
| SCHEMBL28881847 | 0.88 | DNM1 (0.64) | ALDH1A1TSHRDNM1HSP90AA1RAD52 | |
| SCHEMBL11662840 | 0.88 | DNM1 (0.64) | ALDH1A1TSHRDNM1HSP90AA1RAD52 | |
| Sulfuric Acid SCHEMBL28439309 | 0.88 | ALDH1A1 (0.50) | ALDH1A1TSHRDNM1HSP90AA1RAD52 | |
| Hydrochloric Acid SCHEMBL6322596 | 0.86 | DNM1 (0.65) | ALDH1A1TSHRDNM1HSP90AA1RAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0402094-B1 | Process for measuring body fluid components | WAKO PURE CHEM IND LTD (JP) | 1996-08-28 | — | — | EP | disclosed |
| US-5384248-A | Process for measuring an analyte with an oxidase and an oxidizable color reagent and surfactants | WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) | 1995-01-24 | — | — | US | disclosed |