Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.75 |
| ▸ | MAOA | P21397 | 3/20 | 0.75 |
| ▸ | MAOB | P27338 | 2/20 | 0.75 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | ELANE | P08246 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29926081 | 1.00 | MEN1 (0.75) | MEN1KMT2AMAOAMAOBEPHX2 | |
| SCHEMBL27902038 | 0.88 | MEN1 (0.71) | MEN1KMT2AMAOAMAOBEPHX2 | |
| Aloe-Emodin SCHEMBL29814516 | 0.86 | MEN1 (1.00) | MEN1KMT2AMAOAMAOBEPHX2 | |
| Aloe-Emodin SCHEMBL29398579 | 0.86 | MEN1 (1.00) | MEN1KMT2AMAOAMAOBEPHX2 | |
| Aloe-Emodin SCHEMBL309756 | 0.86 | MEN1 (1.00) | MEN1KMT2AMAOAMAOBEPHX2 | |
| SCHEMBL23486119 | 0.84 | MEN1 (0.75) | MEN1KMT2AMAOAMAOBEPHX2 | |
| SCHEMBL11423804 | 0.84 | MEN1 (0.80) | MEN1KMT2AMAOAMAOBEPHX2 | |
| SCHEMBL30293143 | 0.84 | MEN1 (0.80) | MEN1KMT2AMAOAMAOBEPHX2 | |
| SCHEMBL9445895 | 0.83 | MEN1 (0.78) | MEN1KMT2AMAOAMAOBEPHX2 | |
| Aloe-Emodin SCHEMBL8827767 | 0.83 | MEN1 (0.94) | MEN1KMT2AMAOAMAOBEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990008759-A1 | DERIVATIVES OF CHRYSOPHANOL | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-08-09 | — | — | WO | claimed |
| CN-118084744-A | Aloe-emodin derivative and preparation method and application thereof | 广西民族大学 | 2024-05-28 | — | — | CN | disclosed |
| CN-115057850-B | Aloe-emodin derivative and preparation method and application thereof | 中国医学科学院药用植物研究所 | 2023-11-10 | — | — | CN | disclosed |
| CN-115057850-A | Aloe-emodin derivative and preparation method and application thereof | 中国医学科学院药用植物研究所 | 2022-09-16 | — | — | CN | disclosed |
| US-20150203442-A1 | Anthraquinone Analogs and Methods of Making and Using Thereof | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2015-07-23 | — | — | US | disclosed |
| US-20150203442-A1 | Anthraquinone Analogs and Methods of Making and Using Thereof | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2015-07-23 | — | — | US | disclosed |
| WO-2014011753-A2 | ANTHRAQUINONE ANALOGS AND METHODS OF MAKING AND USING THEREOF | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2014-01-16 | — | — | WO | disclosed |
| US-5480873-A | ARTHRITIS | LILLY INDUSTRIES LIMITED (GB) | 1996-01-02 | — | — | US | disclosed |
| EP-0570091-A1 | Anthraquinone derivatives, process for their preparation and their use as medicaments | LILLY INDUSTRIES LIMITED (GB) | 1993-11-18 | — | — | EP | disclosed |
| US-5053431-A | Antitumor-anticarcinogenic agents | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1991-10-01 | — | — | US | disclosed |
| US-4966918-A | ANTICARCINOGENIC AGENTS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-10-30 | — | — | US | disclosed |
| WO-1990008759-A1 | DERIVATIVES OF CHRYSOPHANOL | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-08-09 | — | — | WO | disclosed |
| US-4215062-A | Anthracycline synthesis | UNIVERSITY OF KANSAS ENDOWMENT ASSOCIATION (US) | 1980-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150203442-A1 | Anthraquinone Analogs and Methods of Making and Using Thereof | PCNA, KRAS, RECQL | MEN1 677/4885KMT2A 1122/4885MAOA 3722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.