Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 5/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8996699 | 0.82 | SIGMAR1 (0.52) | EPHX2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8419041 | 0.81 | EPHX2 (0.51) | EPHX2SIGMAR1SLC22A2SLC22A1SLC22A3 | |
| SCHEMBL6720591 | 0.80 | SIGMAR1 (0.52) | EPHX2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6720879 | 0.76 | GRIN2D (0.51) | EPHX2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL9316492 | 0.76 | GRIN2D (0.47) | EPHX2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7493156 | 0.68 | EPHX2 (0.49) | EPHX2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7493162 | 0.68 | EPHX2 (0.49) | EPHX2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL30255695 | 0.68 | EPHX2 (0.60) | EPHX2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29978570 | 0.68 | EPHX2 (0.60) | EPHX2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL6724211 | 0.66 | SIGMAR1 (0.58) | EPHX2GRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5574070-A | Substituted guanidines having high binding to the sigma receptor and the use thereof | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY (US) | 1996-11-12 | — | — | US | disclosed |