Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 5/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9440893 | 0.83 | SIGMAR1 (0.50) | SIGMAR1EPHX2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8996691 | 0.82 | EPHX2 (0.44) | SIGMAR1EPHX2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL6720879 | 0.76 | GRIN2D (0.51) | SIGMAR1EPHX2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL6720591 | 0.75 | SIGMAR1 (0.52) | SIGMAR1EPHX2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8996696 | 0.71 | SIGMAR1 (0.60) | SIGMAR1EPHX2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL9316492 | 0.71 | GRIN2D (0.47) | SIGMAR1EPHX2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL6724211 | 0.70 | SIGMAR1 (0.58) | SIGMAR1EPHX2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL28888905 | 0.65 | EPHX2 (0.76) | EPHX2HDAC3HDAC1HDAC6HDAC2 | |
| SCHEMBL7504154 | 0.65 | EPHX2 (0.50) | SIGMAR1EPHX2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL7504152 | 0.65 | EPHX2 (0.50) | SIGMAR1EPHX2GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5574070-A | Substituted guanidines having high binding to the sigma receptor and the use thereof | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY (US) | 1996-11-12 | — | — | US | disclosed |
| EP-0532642-A4 | — | — | 1994-04-27 | — | — | EP | disclosed |
| EP-0532642-A1 | SUBSTITUTED GUANIDINES HAVING HIGH BINDING TO THE SIGMA RECEPTOR AND THE USE THEREOF | STATE OF OREGON, acting through OREGON STATE BOARD OF HIGHER EDUCATION, acting for OREGON HEALTH SC. UNIV. AND UNIV. OF OREGON (US) | 1993-03-24 | — | — | EP | disclosed |
| WO-1991018868-A1 | SUBSTITUTED GUANIDINES HAVING HIGH BINDING TO THE SIGMA RECEPTOR AND THE USE THEREOF | STATE OF OREGON, acting by and through the OREGON STATE BOARD OF HIGHER EDUCATION, acting for and onbehalf of the OREGON HEALTH SCIENCES UNIVERSITY (US) | 1991-12-12 | — | — | WO | disclosed |