Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 8/20 | 0.52 |
| ▸ | SRD5A1 | P18405 | 7/20 | 0.52 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | SHBG | P04278 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL917575 | 0.83 | SRD5A2 (0.45) | SRD5A2SRD5A1ARSHBG | |
| SCHEMBL8016670 | 0.79 | SRD5A2 (0.55) | SRD5A2SRD5A1ARSHBG | |
| SCHEMBL8084449 | 0.78 | SRD5A2 (0.52) | SRD5A2SRD5A1ARSHBG | |
| SCHEMBL8084448 | 0.78 | SRD5A2 (0.52) | SRD5A2SRD5A1ARSHBG | |
| SCHEMBL7613727 | 0.77 | SRD5A2 (0.51) | SRD5A2SRD5A1AR | |
| SCHEMBL7903652 | 0.77 | SRD5A2 (0.48) | SRD5A2SRD5A1ARSHBG | |
| SCHEMBL7613719 | 0.77 | SRD5A2 (0.51) | SRD5A2SRD5A1AR | |
| SCHEMBL3278549 | 0.76 | SRD5A2 (0.61) | SRD5A2SRD5A1AR | |
| SCHEMBL3276274 | 0.76 | SRD5A1 (0.52) | SRD5A2SRD5A1AR | |
| SCHEMBL8530143 | 0.75 | SRD5A1 (0.47) | SRD5A2SRD5A1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724592-A1 | 16-SUBSTITUTED-4-AZA-ANDROSTANE 5-ALPHA-REDUCTASE ISOZYME 1 INHIBITORS | MERCK & CO. INC. (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995011254-A1 | 16-SUBSTITUTED-4-AZA-ANDROSTANE 5-ALPHA-REDUCTASE ISOZYME 1 INHIBITORS | MERCK & CO., INC. (US) | 1995-04-27 | — | — | WO | disclosed |