Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 5/20 | 0.61 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.61 |
| ▸ | AR | P10275 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3276274 | 0.90 | SRD5A1 (0.52) | SRD5A2SRD5A1AR | |
| SCHEMBL8065832 | 0.88 | SRD5A1 (0.49) | SRD5A2SRD5A1AR | |
| SCHEMBL8065834 | 0.88 | SRD5A1 (0.49) | SRD5A2SRD5A1AR | |
| SCHEMBL8076030 | 0.85 | SRD5A2 (0.57) | SRD5A2SRD5A1AR | |
| SCHEMBL8076036 | 0.85 | SRD5A2 (0.57) | SRD5A2SRD5A1AR | |
| SCHEMBL8075699 | 0.84 | SRD5A1 (0.52) | SRD5A2SRD5A1AR | |
| SCHEMBL8075695 | 0.84 | SRD5A1 (0.52) | SRD5A2SRD5A1AR | |
| SCHEMBL8682928 | 0.83 | SRD5A1 (0.60) | SRD5A2SRD5A1AR | |
| SCHEMBL8712728 | 0.82 | SRD5A1 (0.60) | SRD5A2SRD5A1AR | |
| SCHEMBL4968345 | 0.82 | SRD5A2 (0.54) | SRD5A2SRD5A1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 86 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7696210-B2 | Gonadotropin releasing hormone receptor antagonists | WYETH (US) | 2010-04-13 | — | — | US | disclosed |
| US-7582636-B2 | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-7582634-B2 | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2009-09-01 | — | — | US | disclosed |
| US-7538113-B2 | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2009-05-26 | — | — | US | disclosed |
| US-7534796-B2 | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2009-05-19 | — | — | US | disclosed |
| US-7531542-B2 | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2009-05-12 | — | — | US | disclosed |
| EP-1814866-A2 | GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2007-08-08 | — | — | EP | disclosed |
| EP-1758895-A1 | GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2007-03-07 | — | — | EP | disclosed |
| US-20060270848-A1 | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2006-11-30 | — | — | US | disclosed |
| US-20060264631-A1 | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor | WYETH (US) | 2006-11-23 | — | — | US | disclosed |
| WO-1999051234-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1999-10-14 | — | — | WO | disclosed |
| WO-1999051232-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1999-10-14 | — | — | WO | disclosed |
| WO-1999051233-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1999-10-14 | — | — | WO | disclosed |
| WO-1999041251-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1999-08-19 | — | — | WO | disclosed |
| WO-1999041252-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1999-08-19 | — | — | WO | disclosed |
| WO-1998055479-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1998-12-10 | — | — | WO | disclosed |
| WO-1998055470-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1998-12-10 | — | — | WO | disclosed |
| WO-1998055119-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1998-12-10 | — | — | WO | disclosed |
| WO-1998055123-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1998-12-10 | — | — | WO | disclosed |
| WO-1998055116-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1998-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264631-A1 | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor | GNRHR, GHRHR, LHCGR | SRD5A2 420/4885SRD5A1 491/4885AR 61/4885 |
| US-20060270848-A1 | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of gonadotropin releasing hormone receptor | GNRHR, PRLHR, FSHR | SRD5A2 1661/4885SRD5A1 2217/4885AR 80/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.