Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31569124 | 0.78 | PRMT5 (0.41) | GPR119NR1H2 | |
| SCHEMBL5173942 | 0.78 | PRMT5 (0.41) | GPR119NR1H2 | |
| SCHEMBL691494 | 0.77 | HSD17B10 (0.41) | GPR119USP2SMN1; SMN2CTSKNR1H2 | |
| SCHEMBL4550960 | 0.74 | DDB1 (0.40) | USP2SMN1; SMN2CTSKHSD17B10DDB1 | |
| SCHEMBL31569276 | 0.72 | POLB (0.41) | GPR119 | |
| SCHEMBL16203022 | 0.72 | GHSR (0.47) | NR1H2 | |
| SCHEMBL29673019 | 0.72 | HSD11B1 (0.35) | USP2SMN1; SMN2NR1H2HSD17B10DDB1 | |
| SCHEMBL17980096 | 0.69 | HSD17B10 (0.41) | USP2SMN1; SMN2CTSKHSD17B10HPGD | |
| SCHEMBL2030521 | 0.69 | HSD17B10 (0.41) | USP2SMN1; SMN2CTSKHSD17B10HPGD | |
| SCHEMBL3694111 | 0.69 | HSD17B10 (0.41) | USP2SMN1; SMN2CTSKHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5536737-A | Compound having prolyl endopeptidase inhibitory activity and pharmaceutical use thereof | JAPAN TOBACCO INC. (JP) | 1996-07-16 | — | — | US | disclosed |
| EP-0670309-A1 | COMPOUND WITH PROLYL ENDOPEPTIDASE INHIBITOR ACTIVITY AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 1995-09-06 | — | — | EP | disclosed |