Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | LDHB | P07195 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.30 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.30 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylenediamine SCHEMBL524897 | 1.00 | TDP1 (0.75) | TDP1LMNAALOX15BLMPMP22 | |
| Ethylenediamine SCHEMBL10644761 | 1.00 | TDP1 (0.75) | TDP1LMNAALOX15BLMPMP22 | |
| Ethylenediamine SCHEMBL8679720 | 0.97 | TDP1 (0.71) | TDP1LMNAALOX15BLMPMP22 | |
| SCHEMBL8190449 | 0.88 | TDP1 (0.67) | TDP1LMNAALOX15BLMPMP22 | |
| Putrescine SCHEMBL867233 | 0.88 | TDP1 (0.67) | TDP1LMNAALOX15BLMPMP22 | |
| Ethylamine SCHEMBL6856120 | 0.88 | — | — | |
| SCHEMBL5708652 | 0.87 | TDP1 (1.00) | TDP1LMNAALOX15BLMPMP22 | |
| SCHEMBL2128293 | 0.87 | TDP1 (1.00) | TDP1LMNAALOX15BLMPMP22 | |
| SCHEMBL14870 | 0.87 | — | — | |
| SCHEMBL18279809 | 0.86 | TDP1 (0.63) | TDP1LMNAALOX15BLMPAOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0644181-B1 | AMINO ACID DERIVATIVE AND USE THEREOF | FUJI PHOTO FILM CO LTD (JP) | 1996-09-04 | — | — | EP | disclosed |
| EP-0644181-A1 | AMINO ACID DERIVATIVE AND USE THEREOF | FUJI PHOTO FILM CO., LTD. (JP) | 1995-03-22 | — | — | EP | disclosed |