Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.75 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | LDHB | P07195 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.30 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.30 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylenediamine SCHEMBL8998818 | 1.00 | TDP1 (0.75) | TDP1LMNAALOX15BLMPMP22 | |
| Ethylenediamine SCHEMBL10644761 | 1.00 | TDP1 (0.75) | TDP1LMNAALOX15BLMPMP22 | |
| Ethylenediamine SCHEMBL8679720 | 0.97 | TDP1 (0.71) | TDP1LMNAALOX15BLMPMP22 | |
| SCHEMBL8190449 | 0.88 | TDP1 (0.67) | TDP1LMNAALOX15BLMPMP22 | |
| Putrescine SCHEMBL867233 | 0.88 | TDP1 (0.67) | TDP1LMNAALOX15BLMPMP22 | |
| Ethylamine SCHEMBL6856120 | 0.88 | — | — | |
| SCHEMBL5708652 | 0.87 | TDP1 (1.00) | TDP1LMNAALOX15BLMPMP22 | |
| SCHEMBL2128293 | 0.87 | TDP1 (1.00) | TDP1LMNAALOX15BLMPMP22 | |
| SCHEMBL14870 | 0.87 | — | — | |
| SCHEMBL18279809 | 0.86 | TDP1 (0.63) | TDP1LMNAALOX15BLMPAOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 112 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197940-B1 | POLYMERIZABLE POLYSILOXANES WITH HYDROPHILIC SUBSTITUENTS | ALCON INC (CH) | 2023-02-15 | — | — | EP | disclosed |
| WO-2022270486-A1 | CONTACT LENS AND PRODUCTION METHOD FOR SAID LENS | 日油株式会社 | 2022-12-29 | — | — | WO | disclosed |
| US-20210161772-A1 | RADICAL POLYMERISATION INITIATORS FOR LIGHT-CURABLE DENTAL MATERIALS | DENTSPLY SIRONA INC. (US) | 2021-06-03 | — | — | US | disclosed |
| EP-3390497-B1 | POLYMERIZABLE POLYSILOXANES WITH HYDROPHILIC SUBSTITUENTS | ALCON INC (CH) | 2021-01-20 | — | — | EP | disclosed |
| EP-2931732-B1 | AMPHIPHILIC SILOXANE-CONTAINING VINYLIC MONOMERS AND USES THEREOF | ALCON INC (CH) | 2020-11-25 | — | — | EP | disclosed |
| EP-3419961-B1 | UV/VISIBLE-ABSORBING VINYLIC MONOMERS AND USES THEREOF | ALCON INC (CH) | 2020-09-02 | — | — | EP | disclosed |
| EP-3391100-B1 | AMPHIPHILIC BRANCHED POLYDIORGANOSILOXANE MACROMERS | ALCON INC (CH) | 2020-08-12 | — | — | EP | disclosed |
| US-10676557-B2 | Polymerizable polysiloxanes with hydrophilic substituents | ALCON INC. (CH) | 2020-06-09 | — | — | US | disclosed |
| US-10597479-B2 | Amphiphilic branched polydiorganosiloxane macromers | ALCON INC. (CH) | 2020-03-24 | — | — | US | disclosed |
| EP-3532519-A1 | AMPHIPHILIC BRANCHED POLYDIORGANOSILOXANE MACROMERS | Novartis AG (CH) | 2019-09-04 | — | — | EP | disclosed |
| US-20110196056-A1 | RADICAL POLYMERIZATION INHIBITORS FOR LIGHT-CURABLE DENTAL MATERIALS | BLACKWELL GORDON | 2011-08-11 | — | — | US | disclosed |
| EP-2291167-A2 | RADICAL POLYMERISATION INHIBITORS FOR LIGHT-CURABLE DENTAL MATERIALS | Dentsply DeTrey GmbH (DE) | 2011-03-09 | — | — | EP | disclosed |
| EP-2276446-A1 | RADICAL POLYMERISATION INITIATORS FOR LIGHT-CURABLE DENTAL MATERIALS | Dentsply DeTrey GmbH (DE) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009135677-A1 | RADICAL POLYMERISATION INITIATORS FOR LIGHT-CURABLE DENTAL MATERIALS | DENTSPLY DETREY GMBH (DE) | 2009-11-12 | — | — | WO | disclosed |
| WO-2009135678-A2 | RADICAL POLYMERISATION INHIBITORS FOR LIGHT-CURABLE DENTAL MATERIALS | DENTSPLY DETREY GMBH (DE) | 2009-11-12 | — | — | WO | disclosed |
| US-6274687-B1 | EMULSION POLYMERIZATION | DAISO CO., LTD. (JP) | 2001-08-14 | — | — | US | disclosed |
| US-6046289-A | FOR INHIBITING COAGULATION OF BLOOD PLATELETS, INHIBITING ADHESION OF ANIMAL CELLS, OR AS SUBSTRATE FOR CULTURING ANIMAL CELLS | FUJIFILM CORPORATION (JP) | 2000-04-04 | — | — | US | disclosed |
| US-5763408-A | TUMOR METASTASIS INHIBITORS | FUJI PHOTO FILM CO., LTD. (JP) | 1998-06-09 | — | — | US | disclosed |
| EP-0488258-B1 | Propenamide derivatives, polymers, copolymers and use thereof | FUJI PHOTO FILM CO LTD (JP) | 1996-04-17 | — | — | EP | disclosed |
| EP-0488258-A2 | Propenamide derivatives, polymers, copolymers and use thereof | FUJI PHOTO FILM CO., LTD. (JP) | 1992-06-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110196056-A1 | RADICAL POLYMERIZATION INHIBITORS FOR LIGHT-CURABLE DENTAL MATERIALS | MAP1LC3A, MAP1LC3B, MAP1LC3C | TDP1 1562/4885LMNA 2354/4885ALOX15 1793/4885 |
| US-20210161772-A1 | RADICAL POLYMERISATION INITIATORS FOR LIGHT-CURABLE DENTAL MATERIALS | DNMT3L, PCMT1, DOT1L | TDP1 3618/4885LMNA 945/4885ALOX15 1378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.