Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 8/20 | 0.47 |
| ▸ | DRD5 | P21918 | 8/20 | 0.47 |
| ▸ | DRD2 | P14416 | 7/20 | 0.47 |
| ▸ | DRD3 | P35462 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 5/20 | 0.43 |
| ▸ | SNCA | P37840 | 3/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8999126 | 0.86 | DRD1 (0.47) | DRD1DRD5DRD2DRD3LMNA | |
| SCHEMBL38662728 | 0.85 | DRD1 (0.58) | DRD1DRD5DRD2DRD3LMNA | |
| SCHEMBL6603135 | 0.85 | NOTUM (0.48) | DRD1DRD5DRD2DRD3LMNA | |
| SCHEMBL8998941 | 0.80 | MAPT (0.39) | LMNANOTUM | |
| SCHEMBL578369 | 0.79 | LMNA (0.60) | DRD1DRD5DRD2DRD3LMNA | |
| SCHEMBL29637994 | 0.78 | DRD1 (0.56) | DRD1DRD5DRD2DRD3LMNA | |
| SCHEMBL8999017 | 0.77 | PDE5A (0.39) | NOTUMHSD17B10METAP1 | |
| SCHEMBL8999236 | 0.75 | IDO1 (0.38) | HSD17B10METAP1 | |
| SCHEMBL8999231 | 0.75 | ALDH1A1 (0.41) | NOTUM | |
| SCHEMBL6603783 | 0.75 | DRD1 (0.46) | DRD1DRD5DRD2DRD3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5556874-A | ENZYME INHIBITORS AS ANTICARCINOGENIC AGENTS | WARNER LAMBERT COMPANY (US) | 1996-09-17 | — | — | US | disclosed |
| US-5464861-A | Anticarcinogenic agents | WARNER-LAMBERT (US) | 1995-11-07 | — | — | US | disclosed |
| EP-0654024-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003427-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1994-02-17 | — | — | WO | disclosed |
| US-5030646-A | Treatment of diseases resulting from disfunction of seretoninergic system | ADIR ET COMPAGNIE (FR) | 1991-07-09 | — | — | US | disclosed |