Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 2/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31369140 | 0.85 | GAA (0.56) | AKR1C3SMN1; SMN2LMNAALDH1A1GAA | |
| SCHEMBL3717986 | 0.85 | GAA (0.56) | AKR1C3SMN1; SMN2LMNAALDH1A1GAA | |
| SCHEMBL7483674 | 0.84 | LIG1 (0.59) | SMN1; SMN2LMNAGAAMAPTCNR2 | |
| SCHEMBL11756092 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAGAAMAPTCNR2 | |
| SCHEMBL7479627 | 0.82 | KMT2A (0.60) | SMN1; SMN2LMNAALDH1A1MAPTCES2 | |
| SCHEMBL11189754 | 0.81 | AKR1C3 (0.84) | AKR1C3SMN1; SMN2LMNAALDH1A1TDP1 | |
| SCHEMBL746794 | 0.81 | LMNA (0.64) | SMN1; SMN2LMNAGAACNR2KCNK3 | |
| SCHEMBL2319290 | 0.80 | LMNA (0.47) | SMN1; SMN2LMNAALDH1A1GAACNR2 | |
| SCHEMBL28770832 | 0.80 | AKR1C3 (0.56) | AKR1C3SMN1; SMN2LMNAALDH1A1GAA | |
| SCHEMBL8550050 | 0.79 | TDP1 (0.46) | AKR1C3LMNAALDH1A1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5554624-A | CONGESTIVE HEART FAILURE; HYPOTENSIVE AGENTS | J. URIACH & CIA. (ES) | 1996-09-10 | — | — | US | disclosed |
| EP-0669333-A1 | New imidazopyridine derivatives as angiotensin II antagonists | J. URIACH & CIA. S.A. (ES) | 1995-08-30 | — | — | EP | disclosed |