Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RRM2 | P31350 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27530818 | 0.79 | RRM2 (0.48) | RRM2SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL15467305 | 0.79 | RRM2 (0.48) | RRM2SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL4084675 | 0.77 | RRM2 (0.47) | RRM2SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL17629027 | 0.76 | MEN1 (0.52) | RRM2SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL13199951 | 0.76 | CA12 (0.43) | RRM2SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL10077614 | 0.76 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1KDM4ERAB9ANPC1 | |
| SCHEMBL8415045 | 0.76 | GRM5 (0.50) | SMN1; SMN2ALDH1A1RAB9ANPC1HTT | |
| SCHEMBL17629029 | 0.75 | MEN1 (0.53) | RRM2SMN1; SMN2ALDH1A1KDM4ERAB9A | |
| SCHEMBL4784858 | 0.74 | ALDH1A1 (0.44) | RRM2SMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL4755263 | 0.73 | RRM2 (0.47) | RRM2ALDH1A1KDM4ECDK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729948-A1 | The production of 3-alkylamino-2-piperazinylpyridines | THE UPJOHN COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |