Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | YAP1 | P46937 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8999667 | 1.00 | HRH3 (0.43) | HRH3L3MBTL1MAOBPOLBKDM4E | |
| SCHEMBL2298566 | 0.90 | POLB (0.47) | POLBKDM4ELMNAMCL1ALDH1A1 | |
| SCHEMBL7015459 | 0.90 | POLB (0.47) | POLBKDM4ELMNAMCL1ALDH1A1 | |
| SCHEMBL7015458 | 0.90 | POLB (0.47) | POLBKDM4ELMNAMCL1ALDH1A1 | |
| SCHEMBL7020805 | 0.89 | ALDH1A1 (0.48) | POLBKDM4ELMNAMCL1ALDH1A1 | |
| SCHEMBL7020775 | 0.89 | ALDH1A1 (0.48) | POLBKDM4ELMNAMCL1ALDH1A1 | |
| SCHEMBL30568506 | 0.87 | NPSR1 (0.41) | L3MBTL1POLBKDM4ELMNAMCL1 | |
| SCHEMBL8999682 | 0.86 | POLB (0.43) | POLBKDM4ELMNAMCL1ALDH1A1 | |
| SCHEMBL7021952 | 0.85 | MCL1 (0.45) | POLBKDM4ELMNAMCL1ALDH1A1 | |
| SCHEMBL7021955 | 0.85 | MCL1 (0.45) | POLBKDM4ELMNAMCL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5484780-A | CARDIOVASCULAR, HYPOTENSIVE | ELI LILLY AND COMPANY (US) | 1996-01-16 | — | — | US | disclosed |
| US-5401851-A | Preparation of proline derivatives | ELI LILLY AND COMPANY (US) | 1995-03-28 | — | — | US | disclosed |
| US-5380866-A | Alkyl substituted nitroimidazole acetic acids | ELI LILLY AND COMPANY (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0621269-A1 | Alkyl substituted nitroimidazole acetic acids | ELI LILLY AND COMPANY (US) | 1994-10-26 | — | — | EP | disclosed |
| US-5344937-A | Alkyl substituted nitroimidazole acetic acids | ELI LILLY AND COMPANY (US) | 1994-09-06 | — | — | US | disclosed |
| EP-0573271-A1 | Angiotensin II antagonists | ELI LILLY AND COMPANY (US) | 1993-12-08 | — | — | EP | disclosed |