Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 4/20 | 0.47 |
| ▸ | MMP1 | P03956 | 3/20 | 0.47 |
| ▸ | MMP3 | P08254 | 3/20 | 0.47 |
| ▸ | MMP7 | P09237 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.42 |
| ▸ | FABP7 | O15540 | 1/20 | 0.42 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020805 | 1.00 | ALDH1A1 (0.48) | ALDH1A1NPSR1MMP9MMP1MMP3 | |
| SCHEMBL7015458 | 0.95 | POLB (0.47) | ALDH1A1NPSR1TP53POLBKDM4E | |
| SCHEMBL2298566 | 0.95 | POLB (0.47) | ALDH1A1NPSR1TP53POLBKDM4E | |
| SCHEMBL7015459 | 0.95 | POLB (0.47) | ALDH1A1NPSR1TP53POLBKDM4E | |
| SCHEMBL8999682 | 0.91 | POLB (0.43) | ALDH1A1NPSR1TP53POLBKDM4E | |
| SCHEMBL7021955 | 0.90 | MCL1 (0.45) | ALDH1A1NPSR1TP53POLBKDM4E | |
| SCHEMBL7021952 | 0.90 | MCL1 (0.45) | ALDH1A1NPSR1TP53POLBKDM4E | |
| SCHEMBL8999667 | 0.89 | HRH3 (0.43) | ALDH1A1NPSR1TP53POLBKDM4E | |
| SCHEMBL8999670 | 0.89 | HRH3 (0.43) | ALDH1A1NPSR1TP53POLBKDM4E | |
| SCHEMBL7387119 | 0.89 | POLB (0.45) | ALDH1A1NPSR1MMP9MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115704-B1 | NOVEL SUBSTITUTED INDOLINONES WITH AN INHIBITORY EFFECT ON VARIOUS KINASES AND CYCLIN/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-06-18 | — | — | EP | disclosed |
| US-5693633-A | Angiotensin II antagonists | ELI LILLY AND COMPANY (US) | 1997-12-02 | — | — | US | disclosed |