Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8999783 | 0.99 | AGTR1 (0.35) | L3MBTL1AGTR1AGTR2TAAR1HTR2A | |
| SCHEMBL8999603 | 0.83 | AGTR1 (0.48) | AGTR1AGTR2 | |
| SCHEMBL8999634 | 0.83 | AGTR1 (0.48) | AGTR1AGTR2 | |
| SCHEMBL27333123 | 0.80 | ALDH1A1 (0.31) | L3MBTL1ALDH1A1 | |
| SCHEMBL27342191 | 0.79 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL8999710 | 0.75 | AGTR1 (0.36) | AGTR1AGTR2 | |
| SCHEMBL8999803 | 0.73 | MCL1 (0.33) | — | |
| SCHEMBL8999809 | 0.73 | MCL1 (0.33) | — | |
| SCHEMBL8999761 | 0.73 | MCL1 (0.33) | — | |
| SCHEMBL8999756 | 0.73 | MCL1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5484780-A | CARDIOVASCULAR, HYPOTENSIVE | ELI LILLY AND COMPANY (US) | 1996-01-16 | — | — | US | disclosed |
| US-5401851-A | Preparation of proline derivatives | ELI LILLY AND COMPANY (US) | 1995-03-28 | — | — | US | disclosed |
| EP-0573271-A1 | Angiotensin II antagonists | ELI LILLY AND COMPANY (US) | 1993-12-08 | — | — | EP | disclosed |