SCHEMBL8999910

SCHEMBL8999910

O=C(O)c1ccc(-c2cccc(C(c3cccc(-c4ccc(C(=O)O)c(C(=O)O)c4)c3)(C(F)(F)F)C(F)(F)F)c2)cc1C(=O)O

nearest known ligand 0.47

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
RXRB P28702 3/20 0.47
RXRA P19793 2/20 0.47
PTPN1 P18031 2/20 0.45
ACMSD Q8TDX5 4/20 0.45
ACLY P53396 3/20 0.44
PTPN5 P54829 1/20 0.44
HNF4A P41235 2/20 0.44
MCL1 Q07820 2/20 0.44
DHFR P00374 1/20 0.44
TRPM2 O94759 1/20 0.42
DCLRE1B Q9H816 2/20 0.41
KIF11 P52732 1/20 0.41
KMO O15229 1/20 0.40
DCLRE1A Q6PJP8 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14252238 0.87 RXRA (0.56) RXRBRXRAACLYTRPM2KIF11
SCHEMBL29459104 0.85 RXRB (0.46) RXRBRXRAACMSDACLYHNF4A
SCHEMBL346231 0.85 RXRB (0.46) RXRBRXRAACMSDACLYHNF4A
SCHEMBL9492931 0.81 HSD17B10 (0.50) RXRBRXRA
SCHEMBL1770132 0.81 HSD17B10 (0.50) RXRBRXRA
SCHEMBL109108 0.81 HSD17B10 (0.50) RXRBRXRA
SCHEMBL29441324 0.81 HSD17B10 (0.50) RXRBRXRA
SCHEMBL29401067 0.81 HSD17B10 (0.50) RXRBRXRA
SCHEMBL8999914 0.81 RXRB (0.55) RXRBRXRAPTPN1ACMSDACLY
Water SCHEMBL3223306 0.80 HSD17B10 (0.49) RXRBRXRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5578697-A DIELECTRIC POLYMERS FOR ELECTRONICS KABUSHIKI KAISHA TOSHIBA (JP) 1996-11-26 US disclosed