SCHEMBL8999920

SCHEMBL8999920

Nc1cc(F)cc(Sc2cc(N)cc(F)c2)c1

nearest known ligand 0.38

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.38
TSHR P16473 1/20 0.38
MAPK1 P28482 1/20 0.38
MEN1 O00255 1/20 0.33
MAPT P10636 1/20 0.33
KMT2A Q03164 1/20 0.33
TYMS P04818 1/20 0.32
PDE7A Q13946 1/20 0.30
MAP4K4 O95819 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15122557 0.80 ALDH1A1 (0.32) TSHR
SCHEMBL576508 0.80 CA12 (0.42) MEN1MAPTKMT2ATYMS
SCHEMBL69602 0.76
SCHEMBL1100115 0.76
Fluoride SCHEMBL25262417 0.74 CYP3A4 (0.37) CYP3A4TSHRMAPTMAP4K4
Hydrochloric Acid SCHEMBL30718015 0.74 CA12 (0.42) CYP3A4TSHRMAPTMAP4K4
SCHEMBL10708971 0.72 NR1H2 (0.41) CYP3A4TSHRMAPK1MEN1MAPT
SCHEMBL27874501 0.69 CA12 (0.38) CYP3A4TSHRMAPTMAP4K4
SCHEMBL1100010 0.69 MAP4K4 (0.48) CYP3A4TSHRMAPTMAP4K4
SCHEMBL7185488 0.69 TSHR (0.45) CYP3A4TSHRMAPK1MEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5578697-A DIELECTRIC POLYMERS FOR ELECTRONICS KABUSHIKI KAISHA TOSHIBA (JP) 1996-11-26 US disclosed