Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 6/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000773 | 0.93 | FFAR2 (0.41) | SOAT1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9000793 | 0.91 | SOAT1 (0.37) | SOAT1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9000920 | 0.90 | MAPK1 (0.37) | SOAT1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9000979 | 0.90 | MMP9 (0.38) | SOAT1 | |
| SCHEMBL9000785 | 0.90 | PPARG (0.37) | SOAT1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9000824 | 0.90 | CDC7 (0.37) | SOAT1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9000362 | 0.88 | POLB (0.39) | SOAT1 | |
| SCHEMBL9000778 | 0.87 | PPARG (0.40) | SOAT1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9000757 | 0.86 | KCNQ2 (0.37) | SOAT1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9000680 | 0.85 | SOAT1 (0.45) | EPHX1SOAT1CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |