Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 6/20 | 0.39 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.39 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 2/20 | 0.36 |
| ▸ | EDNRB | P24530 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000680 | 0.85 | SOAT1 (0.45) | SOAT1SOAT2ACAT1SMN1; SMN2NPC1 | |
| SCHEMBL9000818 | 0.84 | SOAT1 (0.41) | SOAT1SOAT2ACAT1 | |
| SCHEMBL9000790 | 0.84 | SOAT1 (0.44) | SOAT1SOAT2ACAT1GAAKMT2A | |
| SCHEMBL9000769 | 0.84 | SOAT1 (0.44) | SOAT1SOAT2ACAT1SMN1; SMN2KMT2A | |
| SCHEMBL9000516 | 0.84 | SOAT1 (0.55) | SOAT1SOAT2ACAT1SMN1; SMN2 | |
| SCHEMBL9000915 | 0.84 | SOAT1 (0.44) | SOAT1SOAT2ACAT1RAB9A | |
| SCHEMBL9000747 | 0.83 | SOAT1 (0.40) | SOAT1SOAT2ACAT1GAAL3MBTL1 | |
| SCHEMBL9000779 | 0.83 | SOAT1 (0.43) | SOAT1SOAT2ACAT1SMN1; SMN2KMT2A | |
| SCHEMBL9000916 | 0.83 | SOAT1 (0.49) | SOAT1SOAT2ACAT1 | |
| SCHEMBL9000962 | 0.83 | SOAT1 (0.43) | SOAT1SOAT2ACAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |