Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 2/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9583180 | 0.98 | KCNN4 (0.50) | KCNN4TAAR1SLC6A2CYP1A2CYP2C9 | |
| SCHEMBL9583515 | 0.86 | SLC6A2 (0.46) | KCNN4TAAR1SLC6A2CYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL9583860 | 0.84 | SLC6A2 (0.44) | KCNN4TAAR1SLC6A2CYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL9582894 | 0.81 | CYP3A4 (0.45) | TAAR1SLC6A2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9001666 | 0.81 | LMNA (0.53) | KCNN4TAAR1SLC6A2CYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL9001665 | 0.79 | LMNA (0.52) | KCNN4TAAR1SLC6A2CYP1A2CYP2C9 | |
| Hydrochloric Acid SCHEMBL9582771 | 0.79 | LMNA (0.52) | KCNN4TAAR1SLC6A2CYP1A2CYP2C9 | |
| SCHEMBL9593242 | 0.77 | SLC6A2 (0.40) | KCNN4TAAR1SLC6A2CYP1A2CYP2C9 | |
| SCHEMBL3056962 | 0.74 | SLC6A2 (0.44) | TAAR1SLC6A2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL10474653 | 0.73 | SIGMAR1 (0.40) | TAAR1SLC6A2CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4968721-A | 2-amino-alpha-phenylphenethylamines and method of use | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-11-06 | — | — | US | claimed |
| US-5489681-A | Method for the preparation of 4-phenyl-1,3-benzodiazepins | HOESCHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1996-02-06 | — | — | US | disclosed |
| US-5349086-A | Method for the preparation of 4-phenyl-1,3-benzodiazepins and precursors thereof | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1994-09-20 | — | — | US | disclosed |
| US-4709093-A | Method for the preparation of 4-phenyl-1,3-benzodiazepines and precursors thereof | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-11-24 | — | — | US | disclosed |
| EP-0082523-B1 | INTERMEDIATES FOR THE PREPARATION OF 4-PHENYL-1,3-BENZODIAZEPINS AND METHODS FOR PREPARING THE INTERMEDIATES | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-04-02 | — | — | EP | disclosed |
| EP-0082523-A2 | Intermediates for the preparation of 4-phenyl-1,3-benzodiazepins and methods for preparing the intermediates | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-06-29 | — | — | EP | disclosed |
| US-4374067-A | Intermediates for the preparation of 4-phenyl-1,3-benzodiazepins and methods for preparing the intermediates | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1983-02-15 | — | — | US | disclosed |
| EP-0066773-A1 | N-(2-(2-amino-2-phenylethyl)phenyl)-2,2-dimethyl-propanamid and derivatives and a process for preparing the same | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1982-12-15 | — | — | EP | disclosed |