Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD2 | O60906 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7453131 | 0.87 | KMT2A (0.47) | SMPD2KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL7453130 | 0.87 | KMT2A (0.47) | SMPD2KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL7289060 | 0.84 | KMT2A (0.42) | SMPD2KMT2AKDM4EALDH1A1PSEN1 | |
| SCHEMBL7470147 | 0.82 | L3MBTL1 (0.50) | SMPD2KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL7443157 | 0.82 | L3MBTL1 (0.50) | SMPD2KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL2327184 | 0.82 | HRH4 (0.40) | SMPD2TRPM8KMT2AL3MBTL1KDM4E | |
| SCHEMBL6113112 | 0.81 | SMPD2 (0.47) | SMPD2SIGMAR1AKR1B1 | |
| SCHEMBL6113113 | 0.81 | SMPD2 (0.47) | SMPD2SIGMAR1AKR1B1 | |
| SCHEMBL6119288 | 0.81 | SMPD2 (0.47) | SMPD2SIGMAR1AKR1B1 | |
| SCHEMBL7142898 | 0.81 | SMPD2 (0.43) | SMPD2KMT2AL3MBTL1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731790-A1 | TACHYKININ ANTAGONISTS | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1996-09-18 | — | — | EP | disclosed |