Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STS | P08842 | 6/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | MGLL | Q99685 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26911742 | 0.87 | NAMPT (0.44) | STSGPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL3813527 | 0.86 | STS (0.62) | STSGPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL31358021 | 0.85 | ALDH1A1 (0.53) | GPR119HSD11B1HPGDKDM4EKMT2A | |
| SCHEMBL13261261 | 0.85 | STS (0.54) | STSGPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL15566640 | 0.85 | STS (0.54) | STSGPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL14655077 | 0.84 | KMT2A (0.56) | STSGPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL1817004 | 0.82 | MGLL (0.54) | STSGPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL13261141 | 0.82 | STS (0.52) | STSGPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL4960694 | 0.81 | POLB (0.58) | GPR119KDM4EPKMKMT2A | |
| SCHEMBL3151354 | 0.81 | POLB (0.61) | GPR119HSD11B1MGLLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5521175-A | CHOLECYSTOKININS AND GASTRIN ANTAGONIST FOR PHYSIOLOGICAL DISORDERS | MERCK SHARP & DOHME LTD. (GB) | 1996-05-28 | — | — | US | disclosed |
| WO-1994003447-A1 | BENZODIAZEPINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-02-17 | — | — | WO | disclosed |