Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL934840 | 0.85 | GPR119 (0.35) | EPHX2SMN1; SMN2USP2CTSKHSD17B10 | |
| SCHEMBL934646 | 0.85 | GPR119 (0.35) | EPHX2SMN1; SMN2USP2CTSKHSD17B10 | |
| SCHEMBL903369 | 0.85 | NR1H2 (0.35) | EPHX2SMN1; SMN2USP2CTSKHSD17B10 | |
| SCHEMBL26782338 | 0.85 | NR1H2 (0.35) | EPHX2SMN1; SMN2USP2CTSKHSD17B10 | |
| SCHEMBL15229449 | 0.84 | EPHX2 (0.35) | EPHX2SMN1; SMN2USP2CTSKHSD17B10 | |
| SCHEMBL25228618 | 0.83 | CTSK (0.35) | EPHX2SMN1; SMN2CTSKHSD17B10KDM1A | |
| SCHEMBL933183 | 0.83 | CTSK (0.35) | EPHX2SMN1; SMN2CTSKHSD17B10KDM1A | |
| SCHEMBL25281618 | 0.82 | HPGD (0.36) | EPHX2SMN1; SMN2CTSKHSD17B10KDM1A | |
| SCHEMBL2420527 | 0.81 | USP2 (0.37) | EPHX2SMN1; SMN2USP2 | |
| Hydrochloric Acid SCHEMBL26107747 | 0.81 | HSD17B10 (0.37) | EPHX2SMN1; SMN2USP2HSD17B10KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5521175-A | CHOLECYSTOKININS AND GASTRIN ANTAGONIST FOR PHYSIOLOGICAL DISORDERS | MERCK SHARP & DOHME LTD. (GB) | 1996-05-28 | — | — | US | disclosed |
| EP-0652873-A1 | BENZODIAZEPINE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1995-05-17 | — | — | EP | disclosed |
| WO-1994003447-A1 | BENZODIAZEPINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-02-17 | — | — | WO | disclosed |