SCHEMBL9003844

SCHEMBL9003844

FC(F)(F)c1ccc(Oc2ccccc2)c(Cl)c1

nearest known ligand 0.71

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 5/20 0.60
KMT2A Q03164 2/20 0.52
MEN1 O00255 1/20 0.52
TTR P02766 1/20 0.52
PPOX P50336 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
MRGPRX4 Q96LA9 7/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
MAPT P10636 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
RAB9A P51151 1/20 0.46
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP2C19 P33261 1/20 0.45
HTR2A P28223 1/20 0.45
SLC6A4 P31645 1/20 0.45
KCNH2 Q12809 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11095176 0.91 FFAR1 (0.65) FFAR1KMT2AMEN1TTRPPOX
SCHEMBL10538095 0.90 NPSR1 (0.57) FFAR1KMT2AMEN1TTRPPOX
SCHEMBL10969104 0.86 FFAR1 (0.60) FFAR1KMT2AMEN1TTRPPOX
SCHEMBL11095171 0.86 KMT2A (0.51) FFAR1KMT2AMEN1TTRPPOX
SCHEMBL11648951 0.85 FFAR1 (0.50) FFAR1KMT2AMEN1TTRPPOX
SCHEMBL10707742 0.85 FFAR1 (0.54) FFAR1KMT2AMEN1TTRPPOX
SCHEMBL11261105 0.84 FFAR1 (0.59) FFAR1MRGPRX4
SCHEMBL28395070 0.84 KMT2A (0.58) FFAR1KMT2AMEN1TTRPPOX
SCHEMBL9132379 0.84 FFAR1 (0.49) FFAR1KMT2AMEN1TTRPPOX
SCHEMBL9582439 0.83 FFAR1 (0.58) FFAR1KMT2AMEN1TTRPPOX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4289909-A Process for preparing 1-dichloroacyl-4-substituted phenoxy benzene and intermediates therefor CHEVRON RESEARCH (US) 1981-09-15 US claimed
EP-2632261-B1 INHIBITORS OF HEPATITIS C VIRUS PRESIDIO PHARMACEUTICALS INC (US) 2016-07-13 EP disclosed
EP-0594179-B1 N-alkoxymethyl benzamide derivative and manufacturing method therefor, and manufacturing method for benzamide derivative using this N-alkoxymethyl benzamide derivate YASHIMA KAGAKU KOGYO KK (JP) 1996-09-25 EP disclosed
US-5354905-A N-alkoxymethyl benzamide derivative and manufacturing method therefor, and manufacturing method for benzamide derivative using this N-alkoxymethyl benzamide derivative YASHIMA CHEMICAL INDUSTRY CO., LTD. (JP) 1994-10-11 US disclosed
EP-0594179-A1 N-alkoxymethyl benzamide derivative and manufacturing method therefor, and manufacturing method for benzamide derivative using this N-alkoxymethyl benzamide derivate YASHIMA CHEMICAL INDUSTRY CO., LTD. (JP) 1994-04-27 EP disclosed
US-4594440-A Solvent extraction RHONE:PULENC, INC. (FR) 1986-06-10 US disclosed
US-4540824-A Diphenyl sulfide compounds useful as intermediates in the production of diphenyl sulfone compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1985-09-10 US disclosed
US-4486223-A PREEMERGENCE AND POSTEMERGENCE HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-12-04 US disclosed
US-4486604-A PRE-AND POSTEMERGENCE HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-12-04 US disclosed
EP-0090870-A1 Diphenyl sulfone compounds, and their production and use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1983-10-12 EP disclosed
US-4405805-A ACIFLUORFEN, XYLENE EXTRACTION RHONE-POULENC, INC. (US) 1983-09-20 US disclosed
US-4374662-A HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1983-02-22 US disclosed
US-4353736-A CROPS OF BARLEY, WHEAT, CORN, RICE OR COATS CIBA-GEIGY CORPORATION (US) 1982-10-12 US disclosed
US-4289909-A Process for preparing 1-dichloroacyl-4-substituted phenoxy benzene and intermediates therefor CHEVRON RESEARCH (US) 1981-09-15 US disclosed
US-4287213-A Dichloroacyl diphenyl ether mite ovacides CHEVRON RESEARCH COMPANY (US) 1981-09-01 US disclosed
US-4219352-A Herbicidal 4-trifluoromethyl-4-nitrodiphenyl ethers ROHM AND HAAS COMPANY (US) 1980-08-26 US disclosed
US-RE30361-E Herbicidal 4-trifluoromethyl-4-nitrodiphenyl ethers ROHM AND HAAS COMPANY (US) 1980-08-05 US disclosed
US-4076741-A Herbicidal 4-trifluoromethyl-4-nitrodiphenyl ethers ROHM AND HAAS COMPANY (US) 1978-02-28 US disclosed
US-3950435-A Herbicidal diphenyl ethers ISHIHARA SANGYO KAISHA LTD. (JA) 1976-04-13 US disclosed