Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxypurinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH known ✓ | P47989 | 7/20 | 0.96 |
| ▸ | TYMP | P19971 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxypurinol SCHEMBL39154 | 0.98 | XDH (1.00) | XDHTYMPGSK3BBACE1JAK2 | |
| Oxypurinol SCHEMBL9823223 | 0.96 | XDH (0.96) | XDHTYMPGSK3BBACE1JAK2 | |
| Oxypurinol SCHEMBL9003893 | 0.96 | XDH (0.96) | XDHTYMPGSK3BBACE1JAK2 | |
| Oxypurinol SCHEMBL9003927 | 0.96 | XDH (0.96) | XDHTYMPGSK3BBACE1JAK2 | |
| Oxypurinol SCHEMBL9295181 | 0.94 | XDH (0.92) | XDHTYMPGSK3BBACE1JAK2 | |
| Oxypurinol SCHEMBL5800680 | 0.79 | XDH (0.66) | XDHTYMPGSK3BBACE1JAK2 | |
| SCHEMBL31495211 | 0.78 | XDH (0.66) | XDHJAK2JAK1TYK2JAK3 | |
| SCHEMBL31495212 | 0.78 | XDH (0.66) | XDHJAK2JAK1TYK2JAK3 | |
| SCHEMBL1719732 | 0.72 | XDH (0.58) | XDHALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL30624853 | 0.72 | XDH (0.58) | XDHALDH1A1MAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5484605-A | Agent for treating chronically inflammatory intestinal diseases | HENNING BERLIN GMBH CHEMIE-UND PHARMAWERK (DE) | 1996-01-16 | — | — | US | disclosed |