Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxypurinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH known ✓ | P47989 | 7/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TYMP | P19971 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxypurinol SCHEMBL9003927 | 0.79 | XDH (0.96) | XDHALDH1A1SMN1; SMN2LMNAJAK2 | |
| Oxypurinol SCHEMBL9003939 | 0.79 | XDH (0.96) | XDHALDH1A1SMN1; SMN2LMNAJAK2 | |
| Oxypurinol SCHEMBL9823223 | 0.79 | XDH (0.96) | XDHALDH1A1SMN1; SMN2LMNAJAK2 | |
| Oxypurinol SCHEMBL9003893 | 0.79 | XDH (0.96) | XDHALDH1A1SMN1; SMN2LMNAJAK2 | |
| Oxypurinol SCHEMBL5800677 | 0.65 | SMN1; SMN2 (0.35) | ALDH1A1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL31495211 | 0.64 | XDH (0.66) | XDHALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL31495212 | 0.64 | XDH (0.66) | XDHALDH1A1SMN1; SMN2LMNAMEN1 | |
| Choline SCHEMBL3628779 | 0.60 | MEN1 (0.50) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| Choline SCHEMBL30396311 | 0.60 | LMNA (0.50) | SMN1; SMN2LMNAMEN1KMT2ACYP3A4 | |
| Choline SCHEMBL3785871 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006083687-A1 | CRYSTAL SALT OF XANTHINE OXIDASE INHIBITORS | CARDIOME PHARMA CORP. (CA) | 2006-08-10 | — | — | WO | disclosed |