Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.42 |
| ▸ | MAPT | P10636 | 9/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | HPGD | P15428 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7257101 | 0.90 | KDM4E (0.40) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL11485433 | 0.85 | LMNA (0.38) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9069378 | 0.85 | C5AR1 (0.40) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL5176140 | 0.82 | SMN1; SMN2 (0.44) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| Trifluoromethanesulfonic Acid SCHEMBL22320986 | 0.81 | KDM4E (0.44) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7251667 | 0.81 | MAPT (0.59) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| Bromide SCHEMBL1797564 | 0.79 | MAPT (0.62) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3937684 | 0.79 | MAPT (0.58) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| Iodide SCHEMBL3292667 | 0.79 | KDM4E (0.58) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10391244 | 0.79 | MAPT (0.41) | KDM4EMAPTALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734574-A1 | OPTICAL VOLUME MEMORY | Lockheed Martin Corporation (US) | 1996-10-02 | — | — | EP | claimed |
| WO-1995016994-A2 | OPTICAL VOLUME MEMORY | LOCKHEED MARTIN CORPORATION (US) | 1995-06-22 | — | — | WO | claimed |
| EP-0734574-A1 | OPTICAL VOLUME MEMORY | Lockheed Martin Corporation (US) | 1996-10-02 | — | — | EP | disclosed |
| WO-1995016994-A2 | OPTICAL VOLUME MEMORY | LOCKHEED MARTIN CORPORATION (US) | 1995-06-22 | — | — | WO | disclosed |