Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.58 |
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | INSR | P06213 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7251667 | 0.98 | MAPT (0.59) | MAPTALDH1A1KDM4EHPGDMEN1 | |
| Bromide SCHEMBL1797564 | 0.96 | MAPT (0.62) | MAPTALDH1A1KDM4EHPGDMEN1 | |
| Iodide SCHEMBL3292667 | 0.96 | KDM4E (0.58) | MAPTALDH1A1KDM4EHPGDMEN1 | |
| Perchlorate SCHEMBL29645224 | 0.91 | MAPT (0.53) | MAPTALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL22320978 | 0.91 | KDM4E (0.53) | MAPTALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL22320973 | 0.91 | MAPT (0.53) | MAPTALDH1A1KDM4EHPGDMEN1 | |
| Perchlorate SCHEMBL5072708 | 0.91 | MAPT (0.53) | MAPTALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL5678577 | 0.82 | KDM4E (0.56) | MAPTALDH1A1KDM4EHPGDMEN1 | |
| Hydrochloric Acid SCHEMBL14333471 | 0.82 | KDM4E (0.51) | MAPTALDH1A1KDM4EHPGDMEN1 | |
| Trifluoromethanesulfonic Acid SCHEMBL22320986 | 0.81 | KDM4E (0.44) | MAPTALDH1A1KDM4EHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044013-B1 | PROCESS FOR PRODUCING 2-HYDROXY-4-(METHYLTHIO)BUTYRATE COMPOUNDS AND INTERMEDIATES THEREOF | SUMITOMO CHEMICAL CO (JP) | 2013-05-29 | — | — | EP | disclosed |
| CN-102702046-A | Process for producing 2-hydroxy-4-(methylthio) butyrate compounds and intermediates thereof | SUMITOMO CHEMICAL CO | 2012-10-03 | — | — | CN | disclosed |
| US-20090192328-A1 | PROCESS FOR PRODUCING 2-HYDROXY-4-(METHLTHIO)BUTYRATE COMPOUNDS AND INTERMEDIATES THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-07-30 | — | — | US | disclosed |
| EP-2044013-A1 | PROCESS FOR PRODUCING 2-HYDROXY-4-(METHYLTHIO)BUTYRATE COMPOUNDS AND INTERMEDIATES THEREOF | Sumitomo Chemical Company, Limited (JP) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008010609-A1 | PROCESS FOR PRODUCING 2-HYDROXY-4-(METHYLTHIO)BUTYRATE COMPOUNDS AND INTERMEDIATES THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2008-01-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192328-A1 | PROCESS FOR PRODUCING 2-HYDROXY-4-(METHLTHIO)BUTYRATE COMPOUNDS AND INTERMEDIATES THEREOF | HAO2, BBOX1, HAO1 | MAPT 2728/4885ALDH1A1 35/4885KDM4E 1863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.